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International R & D courses

Institute of Animal Science - Central ARO Campus, Rishon Leziyon & Rehovot

Department of Ruminant Science

  1. DVIR HAY e-mail Team:Hay Dvir, Vlada Bogol, Mugagga Kalyesubula, Ramgopal Mopuri
    Structural Biology of lipoprotein lipase
    Lipoprotein lipase (LPL) is a key enzyme in the mammalian metabolism. Accordingly, it has clinical significance to many metabolic disorders, particularly of disturbed lipids metabolism, such as hyperchylomicronemia, hypertriglyceridemia, insulin resistance and obesity and cardiovascular disease. However, biochemical characterization of its function is limited since there is no available 3D structure of this enzyme. This project involves the challenging isolation of the native LPL from sheep milk, its biochemical and structural characterization in order to provide basic insight into its function and means of targeting this enzyme for therapeutic development.
    Education requirements
    Philosophy doctor
    Scientific experience
    Biochemist, Structural Biologist.
    Skills
    Protein purification, biochemical characterization, X-ray crystallography
  2. DVIR HAY e-mail Team:Hay Dvir, Vlada Bogol, Mugagga Kalyesubula, Ramgopal Mopuri
    Fatty liver in sheep as a model system for liver disease in human
    Fatty liver (steatosis) develops when the rate of hepatic lipids uptake and synthesis exceeds the rate of their hepatic breakdown and export out of the liver. Steatosis can initiate hepatic inflammation (steatohepatitis) which can progress to liver disease. Although can be caused by excessive alcohol consumption, in the past several decades its prevalence in association with obesity, metabolic syndrome and insulin resistance has reached epidemic prevalence. Fatty liver disease also develops in high-producing ruminants during pregnancy or lactation. We have established an inducible nutritional model of steatosis in lambs. The project aims at studying the pathophysiology of fat related liver disease, and the use of this model to test therapeutic approaches for non-alcoholic fatty liver disease.
    Education requirements
    Doctor of Philosophy
    Scientific experience
    Strong record in any of the following fields is advantageous: Molecular Biology, Ruminants Physiology and Endocrinology.
    Skills
    proteomics, qPCR and statistical analysis
  3. JAMI ELIE e-mail Team:Veronica Reiss
    Exploring the prokaryotic community associated with the rumen ciliate protozoa population
    Ciliate protozoa are an integral part of the rumen microbiome and were found to exert a large effect on the rumen ecosystem itself as well as their host animal physiology. Part of these effects have been attributed to their ability to harbor a diverse ecto- and endo-symbiotic community of prokaryotic cells. Studies on the relationship between the protozoa population and their associated prokaryotic community in the rumen mainly focused on the methanogens, revealing that protozoa play a major role in enhancing methanogenesis potential, emphasizing the importance of studying the protozoal community and their relationship with their associated prokaryotic components. In our lab, we aim to elucidate these cross domain interaction and explore their effect on the host animal.
    Education requirements
    PhD degree
    Scientific experience
    Experienced in lab work, particularly Molecular biology and Microbiology
    Skills
    Bioinformatics skills is an advantage
  4. BARASH ITAMAR e-mail Team:students in the lab
    Manipulating stem cells in the mammary gland
    We shall focus on the interaction of mammary epithelial cells with their (hypothetic) niche and the mechanism involved.
    Education requirements
    Ph.D. studies
    Scientific experience
    Flow cytometry
    Skills
    Molecular biology, hystology

Poultry and Aquaculture

  1. BIRAN YAKOB e-mail Team:Dr. Avner Cnaani E-mail: Jakob@agri.gov.il
    Generating Nile tilapia with heightened appetite using genome editing technology
    We are currently establishing genome-editing approaches for the Nile tilapia (Oreochromis niloticus), one of the world’s most important food fishes. Cocaine and amphetamine regulated transcript (CART) is a neuropeptide that strongly and negatively regulate appetite in fish, and the tilapia genome contains six potential CART genes. The current project aims to: 1. Identify the appetite regulating CART genes in the tilapia genome. 2. Induce loss-of-function mutations in the tilapia CART genes to generate tilapia with increased-appetite. The study will involve molecular work as well as in-vivo experiments in Nile tilapia.
    Education requirements
    PhD in animal science/neuroendocrinology/aquaculture/similar
    Scientific experience
    in-vivo assays in animals and molecular biology
    Skills
    Basic bioinformatics tools (blast etc.). Basic molecular biology skills (PCR, cloning).
  2. BIRAN YAKOB e-mail Team:Adi Hadar jakob@agri.gov.il
    Regulation of alternative splicing in the zebrafish brain
    Pac1 is the cognate receptor of the neuropeptide PACAP. Activity dependent shift in the expression of Pac1 splice-isoforms was previously demonstrated in the brain of zebrafish responding to stress. We have recently developed a Pac1 splice-specific knockout zebrafish. This mutant display perturbed behavioral stress response. The current project aims to: 1. Identify the molecular and cellular pathways regulating the perturbed behavioral response of the knockout fish. 2. Identify novel homeostatic functions regulated by Pac1 isoforms. The study will involve cutting-edge molecular work as well as in-vivo experiments in zebrafish.
    Education requirements
    PhD in animal science/neuroendocrinology/endocrinology/similar
    Scientific experience
    in-vivo assays in animals and molecular biology
    Skills
    Basic bioinformatics tools (blast etc.). Basic molecular biology skills (PCR, cloning). Previous knowledge in MATLAB and/or transcriptome analysis tools is a big advantage.
  3. NOAM MEIRI e-mail Team:Tatiana Kisliouk
    Epigenetic regulation of thermal stress responces in chicks.
    Stressful events in early-life might lead to stress resilience or vulnerability, depending on an adjustable stress-response set-point, which can be altered during postnatal sensory development and involves epigenetic regulation. The aim of the project is to identify those epigenetic markers including DNA methylation histone modifications and micRNA analysis.
    Education requirements
    Doctoral Degree
    Scientific experience
    molecular lab work
    Skills
    Knowledge in molecular biology, advantage in knowledge in brain research.
  4. NOAM MEIRI e-mail Team:Prof. Aron Weller - Bar Ilan University
    Epigenetic regulation of Obesity
    Obesity and metabolic disorders are an ever growing epidemic in the modern world where the access to high fat, energy-dense foods is much easier than before. Maternal high fat diet has long-term consequences on the offspring’s metabolic phenotype which affect the offspring's life and can even be inherited to next generations. This project aims on studying the effects of maternal high fat diet on epigenetics involved in metabolism, stress responses and cognition in the offspring.
    Education requirements
    Doctoral degree
    Scientific experience
    Molecular biology lab experience
    Skills
    Knoledge in techniques in molecular biology, brain research knoledge is an advantage.
Updated on: 01/08/18 12:15
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