אנו מתעניינים בהתפתחות המערכת האנדוקרינית בדגים וכיצד התערבויות בשלבים התפתחותיים מוקדמים משפיעות על תפקוד המערכת האנדוקרינית בשלבים מאוחרים יותר.
הפרוייקטים כוללים:
1. תקשורת בין תאים והשפעתה על נדידת תאי GnRH.
2. תפקוד והתפתחות ציר הורמוני התירואיד במהלך ההתפתחות הלרוולית.
3. תכנות אפיגנטי של ציר התירואיד במהלך ההתפתחות הלרוולית.
4. הבקרה המרכזית (היפותלמוס והיפופיזה) על ציר הורמוני התירואיד.
5. השפעת ציר התירואיד על גדילה בדגים.
שיטות העבודה במעבדה כוללות ביולוגיה מולקולרית, ערכיה גנומית בדגים, ייצור דגים טרנסגניים, מגוון שיטות פיזיולוגיות ואימג'ינג.
פירסומים:
1. Aizen , J., Kasuto, H., Golan , M., Zakay, H., and Levavi-Sivan, B. (2007). Tilapia Follicle-Stimulating Hormone (FSH): Immunochemistry, Stimulation by Gonadotropin-Releasing Hormone, and Effect of Biologically Active Recombinant FSH on Steroid Secretion. Biology of Reproduction 76, 692-700
2. Golan, M. and Levavi-Sivan, B. (2013). Social dominance in tilapia is associated with gonadotroph hyperplasia. General and Comparative Endocrinology, 192:126-35.
3. Zmora, N., Stubblefield, J., Golan, M., Servili, A., Levavi-Sivan, B. and Zohar, Y. (2014). The medio-basal hypothalamus as a dynamic and plastic reproduction-related kisspeptin-gnrh-pituitary center in fish. Endocrinology. 2014 May;155(5):1874-86.
4. Golan, M. and Levavi-Sivan, B. (2014). Artificial masculinization in tilapia involves androgen receptor activation. General and Comparative Endocrinology. 207, 50-55.
5. Bloch, C.L., Kedar, N., Golan, M., Gutnick, M.J., Fleidervish, I.A. and Levavi-Sivan, B. (2014). Long-term GnRH-induced gonadotropin secretion in a novel hypothalamo-pituitary slice culture from tilapia brain. General and Comparative Endocrinology. 207, 21-27.
6. Biran, J., Golan, M., Mizrahi, N., Ogawa, S., Parhar, I.S. and Levavi-Sivan, B. (2014). LPXRFa, the Piscine Ortholog of GnIH, and LPXRF Receptor Positively Regulate Gonadotropin Secretion in Tilapia (Oreochromis niloticus). Endocrinology. 155(11):4391-401.
7. Biran, J., Golan, M., Mizrahi, N., Ogawa, S., Parhar, I.S. and Levavi-Sivan, B. (2014). Direct Regulation of Gonadotropin Release by Neurokinin B in Tilapia (Oreochromis niloticus) Endocrinology. 155(12), 4831-42.
8. Golan, M., Biran, J. and Levavi-Sivan, B (2014). A novel model for development, organization and function of gonadotrophs in fish pituitary. Frontiers in Endocrinology. doi: 10.3389/fendo.2014.00182
9. Golan, M., Zelinger, E., Zohar, Y., and Levavi-Sivan, B. (2015). Architecture of GnRH-Gonadotrope-Vasculature Reveals a Dual Mode of Gonadotropin Regulation in Fish. Endocrinology. 156(11), 4163-73. The article was chosen for the cover and for an editorial review in the November issue.
10. Ogawa, S., Sivalingam, M., Biran, J., Golan, M., Anthonysamy, R., Levavi-Sivan, B. and Parhar, I. S. (2016). Distribution of LPXRFa, a Gonadotropin-inhibitory hormone (GnIH) ortholog peptide and LPXRFa Receptor in the Brain and Pituitary of the Tilapia. Journal of Comparative Neurology. 524(14):2753-75. doi: 10.1002/cne.23990. Epub 2016 Mar 7.
11. Golan, M., Martin, A. O., Mollard, P. and Levavi-Sivan, B. (2016). Anatomical and functional gonadotrope networks in the teleost pituitary. Sci. Rep. 6:23777. doi: 10.1038/srep23777.
12. Golan, M., Hollander-Cohen, L. and Levavi-Sivan, B. (2016). Stellate Cell Networks in the Teleost Pituitary. Sci. Rep. 6:24426. doi: 10.1038/srep24426.
13. Yom-Din S., Hollander-Cohen L., Aizen J., Boehm B., Shpilman M., Golan M., Hurvitz A., Degani G., Levavi-Sivan B. (2016). Gonadotropins in the Russian Sturgeon: Their Role in Steroid Secretion and the Effect of Hormonal Treatment on Their Secretion. PLoS One. 11(9):e0162344. doi:10.1371/journal.pone.0162344. eCollection 2016.
14. Spicer OS, Zmora N, Wong TT, Golan M, Levavi-Sivan B, Gothilf Y, Zohar Y. (2017). The gonadotropin-inhibitory hormone (Lpxrfa) system's regulation of reproduction in the brain-pituitary axis of the zebrafish (Danio rerio). Biol Reprod. 96(5):1031-1042. doi: 10.1093/biolre/iox032.
15. Hollander-Cohen, L., Golan, M., Aizen, J., Shpilman, M. and Levavi-Sivan, B. (2018). Characterization of carp gonadotropins: Structure, annual profile, and carp and zebrafish pituitary topographic organization.
Gen. Comp. Enocrinol. 264:28-38.
16. Etzion, T., Zmora, N., Zohar, Y., Levavi-Sivan, B., Golan, M. and Gothilf, Y. (2020). Ectopic Over Expression of kiss1 May Compensate for the Loss of kiss2. Gen. Comp. Endocrinol. doi: 10.1016/j.ygcen.2020.113523.
17. Santiago-Andres Y, Golan M, Fiordelisio T. (2020). Functional pituitary networks in vertebrates. Frontiers in Endocrinology. doi: 10.3389/fendo.2020.619352.
18. Golan, M., Boulanger-Weill, J., Pinot, A., Fontanaud, P., Faucherre, A., Gajbhiye, D. S.PD, Hollander-Cohen, L., Fiordelisio-Coll, T., Martin, A.O., and Mollard, P. (2021). Synaptic communication mediates the assembly of a self-organizing circuit that controls reproduction. Science Advances, Vol. 7, no. 8, eabc8475, doi: 10.1126/sciadv.abc8475
19. Hollander-Cohen, L., Golan, M. and Levavi-Sivan, B. (2021). Differential Regulation of Gonadotropins as Revealed by Transcriptomes of Distinct LH and FSH Cells of Fish Pituitary. Int. J. Mol. Sci. 2021, 22, 6478. https://doi.org/ 10.3390/ijms22126478
20. Mapunda, J., Mtolera, M. S. P., Yahya, S. A. S., Ngo, V. M., Golan, M. and Nguyen, V. M. (2021). Effect of tank colour on growth, survival, stress level, digestive enzymatic activities and body composition of snubnose pompano (Trachinotus blochii Lacépède) larvae. Aquac. Res. doi: 10.1111/are.15487
21. Mapunda, J., Mtolera, M. S. P., Yahya, S. A. S., Ngo, V. M. and Golan, M. (2021). Light colour affect the survival rate, growth performance, cortisol level, body composition, and digestive enzymes activities of different Snubnose pompano (Trachinotus blochii (Lacépède, 1801) larval stages. doi: https://doi.org/10.1016/j.aqrep.2021.100804
22. Gajbhiye D.S., Oz, I., Columbus-Shenkar, Y., Golan, M. (2021). Larval development staging table for hatchery-reared sunshine bass (Morone chrysops? x Morone saxatilis?). Aquaculture, In press, https://doi.org/10.1016/j.aquaculture.2021.737379