We study regulatory bioenergetics: how mitochondrial carbon flux and redox balance are coordinated under metabolic and environmental stress, and how this regulation can be deliberately modulated to prevent metabolic collapse.
Our research integrates whole-animal physiology, cellular bioenergetics, and molecular approaches to uncover actionable control points within the mitochondrial stress-response network. Applications span metabolic disorders in mammals and stress resilience in agricultural systems.
Specific Applications:
- Ketosis and Pregnancy Toxemia in Sheep
- Fatty Liver in livestock, and as a translational model of human NAFLD
- Diabetic Ketosis
In parallel, we investigate the regulatory impact of targeted cofactors and substrates — including thiamine, fatty acids, and glycerol on mitochondrial respiration, redox balance, and bioenergetic stability. Our goal is to develop mechanism-based metabolic interventions to restore metabolic adaptive capacity under stress.
