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שלח באימייל הדפס
Name: Eyal Seroussi, Ph.D. (Researcher)
Units: Animal ScienceDepartment of Ruminant Science
Research Interests / Job description  
Tel:  08-9484425
Email:    seroussi@agri.huji.ac.il
Address:Department of Quantitative and Molecular Genetics
Institute of Animal Science
Agricultural Research Organization,
The Volcani Center,
HaMaccabim Road, Rishon LeTsiyon, P.O.B 15159, 7528809, Israel


Research Interests / Job description
Animal genomics, genetics and bioinformatics.

Research Interests

Publications (past 12 years, out of 98 in the full list)

Golik, M., Glick, G., Reicher, S., Shirak, A., Ezra, E., Zeron, Y., Gootwine, E., Ron, M., Weller, J.I., Seroussi E. (2011) Differential expression of ruminant ZNF496 variants: Association with QTL affecting bovine milk concentration and fertility. J. Dairy Sci. 94:2092-2102.

Reicher, S., Gertler, A., Seroussi, E., Shpilman, M., Gootwine, E. (2011) Biochemical and in-vitro biological significance of natural sequence variation in the ovine leptin gene. Gen. Comp. Endocrinol. 173:63-71.

Seroussi, Y., Shirak, A., Seroussi, E. (2011) SNPmplexViewer--toward a cost-effective traceability system. BMC Res. Notes 4:146.

Glick, G., Shirak, A., Seroussi, E., Zeron, Y., Ezra E., Weller, J.I . Ron, M. (2011) Fine mapping of a QTL for fertility on BTA7 and its association with a CNV in the Israeli Holsteins. G3 1:65-74.

Seroussi, E., Yakobson, E., Garazi, S., Oved, Z. Halachmi I. (2011) Long-term survival of flag ear-tags on an Israeli dairy farm. J. Dairy Sci. 94:5533-5.

Reicher, S., Seroussi, E., Weller, J.I., Rosov, A., Gootwine, E. (2012) Ovine mitochondrial DNA sequence variation and its association with production and reproduction traits within an Afec-Assaf flock. J. Anim. Sci. 90:2084-91.

Glick, G., Shirak, A., Uliel, S., Zeron, Y., Ezra, E., Seroussi, E., Ron, M., Weller, J.I. (2012) Signatures of contemporary selection in the Israeli Holstein dairy cattle. Anim. Genet. 43 Suppl 1:45-55.

Shirak, A., Reicher, S., Uliel, S., Mehlman, T., Shainskaya, A., Ron, M., Seroussi, E. (2012) Gender and sexual behavior modulate the composition of serum lipocalins in Nile tilapia (Oreochromis niloticus). Gene 504:22-30.

Shirak, A., Palti, Y., Bern, O., Kocher, T. D., Gootwine, E., Seroussi, E., Hulata, G., Ron, M., Avtalion, R. R. (2013) A deleterious effect associated with UNH159 is attenuated in twin embryos of an inbred line of blue tilapia Oreochromis aureus J. Fish Biol. 82:42-53.

Shirak, A., Barkai, O., Lernau, O., Kahanov, Y., Seroussi, E., Ron, M. (2013) DNA barcoding analysis of fish bones from a shipwreck found at Dor, Israel.  Israeli J. Aquaculture-Bamidgeh 65: 873.

Seroussi, E., Glick, G., Shirak, A., Ezra, E., Zeron, Y., Ron, M., Weller, J.I. (2013) Maternity validation using sire-only BovineSNP50 BeadChip data. Anim. Genet. 44:754-757.

Gertler, A., Shinder, D., Yosefi, S., Shpilman, M., Rosenblum, C.I., Ruzal, M., Seroussi, E., Friedman-Einat, M. (2013) Pegylated leptin antagonist with strong orexigenic activity in mice is not effective in chickens. J. Exper. Biol. 217: 180-184.

Seroussi, E., Klompus, S., Silanikove, M., Krifucks, O., Shapiro, F., Gertler, A., Leitner, G. (2013) Non-bactericidal secreted phospholipase A2s are potential anti-inflammatory factors in the mammary gland. Immunogenetics 65: 861-871.

Weller, J.I, Glick, G., Shirak, A., Ezra, E., Seroussi, E., Shemesh, M., Zeron, Y., Ron, M. (2013) Predictive ability of selected subsets of single nucleotide polymorphisms (SNPs) in a moderately sized dairy cattle population. Animal 8: 208-216.

Friedman-Einat, M., Cogburn, L. A., Yosefi, S., Hen, G., Shinder, D., Shirak A., Seroussi, E. (2014) Discovery and characterization of the first genuine avian leptin gene in the rock dove (Columba livia). Endocrinology 155: 3376-3384.

Dor, L., Shirak, A., Gorshkov, S., Band, M. R., Korol, A., Ronin, Y., Curzon, A., Hulata, G., Seroussi, E., Ron, M. (2014) Construction of a microsatellites-based linkage map for the White Grouper (Epinephelus aeneus). G3 4:1455-1464.

Friedman-Einat, Seroussi, E. (2014) Quack leptin. BMC genomics 15:551.

Eshel, O., Shirak, A., Dor, L., Band, M., Zak, T., Markovich-Gordon, M., Chalifa-Caspi, V., Feldmesser, E., Weller, J. I., Seroussi, E., Hulata, G. and Ron, M. (2014) Identification of male-specific amh duplication, sexually differentially expressed genes and microRNAs at early embryonic development of Nile tilapia (Oreochromis niloticus) BMC Genomics 15:774.

Ronkin, D., Seroussi, E., Nitzan, T., Doron-Faigenboim, A. and Cnaani, A. (2015) Intestinal transcriptome analysis revealed differential salinity adaptation between two tilapiine species. Comp. Biochem. Physiol. Part D Genomics Proteomics 13:35-43.

Seroussi, E., Cinnamon, Y., Yosefi, S., Genin, O., Gage-Smith, J., Rafati, N., Bornelöv, S., Andersson, L. and Friedman-Einat, M. (2015) Identification of the long-sought leptin in chicken and duck: expression pattern of the highly GC-rich avian leptin fits an autocrine/paracrine rather than endocrine function. Endocrinology 157:737-751.

Shirak, A., Dor, L., Seroussi, E., Ron, M., Hulata, G. and Golani, D. (2015). DNA barcoding of fish species from the Mediterranean coast of Israel. Mediterranean Mar. Sci. 17: 2.

Dor L., Shirak A., Rosenfeld H., Ashkenazi I.M., Band M.R., Korol A., Ronin Y., Seroussi, E., Weller, J.I. and Ron, M. (2016). Identification of the sex-determining region in flathead grey mullet (Mugil cephalus). Anim. Genet. 47:698-707.

Seroussi, E., Rosov, A., Shirak, A., Lam, A. and Gootwine, E. (2017). Unveiling genomic regions that underlie differences between Afec-Assaf sheep and its parental Awassi breed. Genet Sel Evol. 49:19.

Gootwine, E., Abu-Siam, M., Obolensky, A., Rosov, A., Honig, H., Nitzan, T., Shirak, A., Ezra-Elia, R., Yamin, E., Banin, E., Averbukh, E., Hauswirth, W.W., Ofri, R., and Seroussi, E. (2017). Gene augmentation therapy for a missense substitution in the cGMP-binding domain of ovine CNGA3 gene restores vision in day-blind sheep. Invest. Ophthalmol. Vis. Sci. 58:1577-1584.

Shirak, A., Seroussi, U., Gootwine, E. and Seroussi, E. (2017). Sequence motifs capable of forming DNA stem-loop structures act as a replication diode. FEBS Open Bio. 7:944-952

Bornelöv, S., Seroussi, E., Yosefi, S., Pendavis, K., Burgess, S.C., Grabherr, M., Friedman-Einat, M., and Andersson, L. (2017) Identification of chicken genes previously assumed to be evolutionarily lost. Genome Biol. 18:112.

Seroussi, E., Pitel, F., Leroux, S., Morisson, M., Bornelöv, S., Miyara, S., Yosefi, S., Cogburn, L.A., Burt, D.W., Andersson, L. and Friedman-Einat, M. (2017) Mapping of leptin and its syntenic genes to chicken chromosome 1p. BMC Genet. 18:77.Sasson, G., Kruger

Ben-Shabat, S., Seroussi, E., Doron-Faigenboim, A., Shterzer, N., Yaacoby, S., Berg Miller, M.E., White, B.A., Halperin, E. and Mizrahi, I. (2017) Heritable Bovine Rumen Bacteria are phylogenetically related and correlated with the cow's capacity to harvest energy form its feed. mBio 8:e00703-17

Bornelöv, S., Seroussi, E., Yosefi, S., Benjamini, S., Miyara, S., Ruzal, M., Grabherr, Rafati, N., Molin, A. M., Pendavis, K., Burgess, S.C., M., Andersson, L., and Friedman-Einat, M. (2018) Comparative omics and feeding manipulations in chicken indicate a shift of the endocrine role of visceral fat towards reproduction. BMC Genomics; 19:295.

Shen, B., Jiang, J., Seroussi, E., Liu, G.E., and Ma, L. (2018) Characterization of recombination features and the genetic basis in multiple cattle breeds. BMC Genomics; 19:304.

Dor, L., Shirak, A., Rosenfeld, H., Meiri-Ashkenazi, I., Rubinstein, G., Seroussi, E., Weller, J.I., and Ron, M. (2018). Genetic stock identification of the flathead grey mullet (mugil cephalus) in lake Tiberias based on parent offspring relationship. Isr. J. Aquacult.-Bamid. 70.

Shirak, A., Zak, T., Dor, L., Benet-Perlberg, A., Weller, J.I., Ron, M., and Seroussi, E. (2018). Quantitative trait loci on LGs 9 and 14 affect the reproductive interaction between two Oreochromis species, O. niloticus and O. aureus. Heredity 122: 341-353

Seroussi, E., Blum, S.E., Krifucks, O., Yaniv Lavon Y. and Leitner, G. (2018). Application of pancreatic phospholipase A2 for treatment of bovine mastitis. PLoS ONE 13: e0203132.

Liu, M., Fang, L., Liu, S., Pan, MG., Seroussi, E., Cole, JB., Ma, L., Chen, H., and Liu, GE. (2019). Array CGH-based detection of CNV regions and their potential association with reproduction and other economic traits in Holsteins.  BMC Genomics 20: 181.

Seroussi, E., Shirak, A., Gershoni, M., Ezra, E., de Abreu Santos, DJ., Ma, L., Liu, GE. (2019). Bos taurusindicus hybridization correlates with intralocus sexual-conflict effects of PRDM9 on male and female fertility in Holstein cattle. BMC Genet. 20:71.

Seroussi, E., Knytl, M., Pitel, F., Elleder, D., Krylov, V., Leroux, S., Morisson, M., Yosefi, S., Miyara, S., Ganesan, S., Ruzal, M., Andersson, L. and Friedman-Einat, M. (2019). Avian expression patterns and genomic mapping implicate leptin in digestion and TNF in immunity, suggesting that their interacting adipokine role has been acquired only in mammals. Int J Mol Sci 20: 4489.

Dor, L., Shirak, A., Kohn, YY., Gur, T., Weller, JI. Zilberg, D., Seroussi, E., and Ron, M. (2019). Mapping of the sex determining region on linkage group 12 of Guppy (Poecilia reticulate). G3-Genes Genom. Genet. 9:3867-3875.

Curzon, AY., Shirak, A., Dor, L., Zak, T., Perelberg, A., Seroussi, E. and Ron, M. (2019). The hybrid origin of the Thai-Chitralada Tilapia strain using DNA barcoding and microsatellite analysis.  Isr. J. Aquacult.-Bamid. 71.

Friedman-Einat, M. and Seroussi, E. (2019). Avian Leptin: Bird's-Eye View of the Evolution of Vertebrate Energy-Balance Control. Trends Endocrinol. Metabol. 30: 819-832.

Curzon, AY., Shirak, A., Dor, L., Zak, T., Benet-Perlberg, A., Seroussi, E., and Ron, M. (2020). A duplication of the Anti-Müllerian hormone gene is associated with genetic sex determination of different Oreochromis niloticus strains. Heredity 125:317-327.

Dor, L., Shirak, A., Curzon, A.Y., Rosenfeld, H., Ashkenazi, IM., Nixon, O., Seroussi, E., Weller, JI., and Ron, M. (2020). Preferential Mapping of Sex-Biased Differentially-Expressed Genes of Larvae to the Sex-Determining Region of Flathead Grey Mullet (Mugil cephalus). Front. Genet. 11:839.

Seroussi, E., Blum, SE., Krifucks, O., Shirak A., Jacoby S., and Leitner, G. (2020). Basal levels of CD18 antigen presenting cells in cow milk associate with copy number variation of Fc gamma receptors. Genes 11:952.

Curzon, A.Y., Dor, L., Shirak, A., Ashkenazi, IM., Rosenfeld, H., Ron, M., and Seroussi, E. (2020). A novel c.1759T>G variant in Follicle-stimulating hormone-receptor gene is concordant with male determination in the flathead grey mullet (Mugil cephalus). G3-Genes Genom. Genet. 11:jkaa044

Seroussi, E. (2021). Estimating copy-number proportions: The comeback of Sanger sequencing. Genes 12:283.

Curzon, AY., Shirak, A., Zak, T., Benet-Perlberg, A., Naor, A., Low-Tanne, S.I., Sharkawi, H., Ron, M., and Seroussi, E. (2021). All-male production by marker-assisted selection for sex determining loci of admixed Oreochromis niloticus and O. aureus stocks. Anim. Genet. 52:361-364.

Curzon, AY., Shirak, A., Zak, T., Benet-Perlberg, A., Naor, A., Low-Tanne, S.I., Sharkawi, H., Ron, M., and Seroussi, E. (2021). Gene variant of barrier to autointegration factor 2 (banf2w) is concordant with female determination in cichlids. Int. J. Mol. Sci. 22:7073.

Yang, L., Gao, Y., Li, M., Park, K., Liu, S., Kang, X., Liu, M., Oswalt, A., Fang, L., Telugu, B.P., Sattler, C.G., Li, C., Cole, J.B., Seroussi, E., Xu, L., Yang, L., Yang, Z., Li, L., Zhang, H., Rosen, B.D, Van Tassell C.P, Ma, L., and Liu, G.E. (2022). Genome-wide recombination map construction from single sperm sequencing in cattle. BMC Genomics 23:181.

Gershoni, M., Shirak, A., Raz, R., and Seroussi, E. (2022). Comparing BeadChip and WGS Genotyping: Non-Technical Failed Calling Is Attributable to Additional Variation within the Probe Target Sequence. Genes 13:485.

Curzon, AY., Shirak, A., Meerson, A., Degani, G., Hurvitz, A., Ben-Naim, N., Domovitz, R., Ron, M., and Seroussi, E. (2022). Cross-species conservation of a transposase-linked element enables genetic sexing of commercial populations of Russian sturgeon (Acipenser gueldenstaedtii). Anim. Genet. https://doi.org/10.1111/age.13188 

Yang, L., Gao, Y., Oswalt, A., Fang, L., Boschiero, C., Neupane, M., Sattler, C.G., Li, C., Seroussi, E., Xu, L., Yang, L., Yang, Z., Li, L., Zhang, H, Rosen, B.D, Van Tassell, C.P., Zhou, Y., Ma, L., and Liu, G.E. (2022). Towards the detection of copy number variation from single sperm sequencing in cattle. BMC Genomics 23:215.

Curzon, AY., Shirak, A., Zak, T., Benet-Perlberg, A., Naor, A., Low-Tanne, S.I., Sharkawi, H., Ron, M., and Seroussi, E. (2022). Absence of Figla-like gene is concordant with femaleness in cichlids harboring the LG1 sex-determination system. Int. J. Mol. Sci. 23:7636.

Gershoni, M., Shirak, A., Ben-Meir, Y., Shabtay, A., Cohen-Zinder M., and Seroussi, E. (2023). Re-evaluation of genotyping methodologies in cattle: the proficiency of imputation. Genes 14:547.

Weller, JI., Ezra, E., Seroussi, E., and Gershoni, M. (2023). Genetic and genomic analysis of cow mortality in the Israeli Holstein population. Genes 14:588.

Curzon, AY., Shirak, A., Ron, M., and Seroussi, E. (2023). Master-key regulators of sex determination in fish and other vertebrates—A review. Int. J. Mol. Sci. 24: 2468.


 Current Projects

  • Genes affecting economic traits of dairy cattle, sheep and chicken.
  • Linkage disequilibrium mapping of QTLs and pedigree based haplotype reconstruction.
  • Applying machine learning to the prediction of breeding values for quantitative traits using genetic markers.
  • Traceability.
  • Copy number variation in cattle and fish.


Updated on: 26/02/23 16:31
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