Non-alcoholic fatty liver disease (NAFLD) is a rising epidemic associated with overnutrition and thus with obesity, type II diabetes and metabolic syndrome.
Although high-producing ruminants can spontaneously develop fatty liver disease during late pregnancy and early lactation, it is in fact as a result of insufficient dietary intake, therefore not well reflecting the initiation of the disease in human.
We have recently established a nutritional model for fatty liver in sheep which is based on high-calorie diet at limited physical activity. This novel large-animal model allows for investigation of the capacity of various treatments to modulate hepatic steatosis, and can serve as a sensitive and well-controlled platform for pre-clinical testing of potential therapies.
Research in the lab is focused on:
Pathophysiology of fatty liver in sheep.
Development of therapies for pregnancy toxemia and ketosis.
NAFLD and metabolic syndrome from sheep to human.
Structural Biology of lipolytic enzymes.
1. Kalyesubula, M., Rosov, A., Alon, T., Moallem, U., Dvir, H*. Intravenous infusions of glycerol versus propylene glycol for the regulation of negative energy balance in sheep: A randomized trial (2019). Animals. 9(10):731.
2. Dvir, H*. Kornitzer, D*. CFEM Protein Csa2 (2018). Encyclopedia of Inorganic and Bioinorganic Chemistry Online, John Wiley & Sons.
3. Nasser, L. Weissman, Z. Pinsky, M. Amartely, A. Dvir, H.* and Kornitzer, D.*. Heme-iron acquisition by fungal pathogens (2016). Nature Microbiology 12;1(11):16156.
4. Dvir, H*. Shah, M. Girardi, E. Guo, Ls. Farquhar, M.G and Zajonc, D.M. Atomic structure of the autosomal recessive hypercholesterolemia phosphotyrosine-binding domain in complex with the LDL-receptor tail (2012). PNAS 109 (18) 6916-21.
5. Dvir, H. Wang, J. Ly, N. Dascher, C.C. and Zajonc, D.M. Structural basis for lipid antigen recognition in avian immunity (2010). Journal of Immunology, 184 (5) 2504-11. Editor’s Highlight.
6. Dvir, H. Harel, M. Bon, S. Liu W.Q. Garbay, C. Sussman, J.L. Massoulié, J. and Silman, I. The Synaptic Acetylcholinesterase Tetramer Assembles Around a Polyproline-II Helix (2004). EMBO Journal 23 (22) 4394-405.
7. Dvir, H. Harel, M. McCarthy, A.H. Toker, L. Silman, I. Furterman, A.H. and Sussman, J.L. X-ray structure of human acid b-glucosidase, the defective enzyme in Gaucher disease (2003). EMBO Reports 4 (7) 1-6.
8. Prafulla, A. Dvir, H. Choe, S. and Slesinger, P.A. Evidence for a discrete alcohol pocket involved in GIRK channel activation (2009). Nature Neuroscience, 12 (8) 988-985.
9. Dvir, H. Silman, I. Harel, M. Rosenberry, T and Sussman, J.L. Acetylcholinesterase: From 3D Structure to Function (2010). Chemico-Biological Interactions, 187 (1-3) 10-22.
10. Dvir, H. Valera, E. and Choe, S. Structure of the MthK RCK in complex with cadmium (2010). Journal of Structural Biology, 171 (2) 231-7.
11. Dvir, H. Wong, D.M. Harel, M. Barril, X. S. Orozc, M. Luque, F.J. Munoz-Torrero, D. Camps, P. Rosenberry, T.L. Silman, I. and Sussman, J.L. 3D structure of Torpedo californica acetylcholinesterase complexed with Huprine X at 2.1 Å resolution: kinetic and molecular dynamic correlates (2002). Biochemistry 41 (9) 2970-81.
12. Dvir, H. Jiang, H.L. Wong, M.D. Harel, M. Chetrit, M. He, X.C. Jin, G.Y. Yu, G.L. Tang, X.C. Silman, I. Bai, D.L. and Sussman, J.L. X-ray structures of Torpedo californica acetylcholinesterase complexed with (+)-Huperzine A and (-)-Huperzine B: Structural evidence for an active site rearrangement (2002). Biochemistry 41 (35) 10810-8.
- Postdoctoral position Liver Metabolism & Sheep Physiology.
- Postdoctoral position in Diabetic Sheep & Therapy.
- M.Sc. and Ph.D. positions in Fatty Liver Pathophysiology.