WEBSITE

https://mirik28.wixsite.com/elenapoverenov

Announcements

Open positions for MSc and PhD students and Postdocs

Lab members

Yael Cohen (for PhD)

Rafael Izhakov (for PhD)

Yevgenia Shebes (for PhD)

Aviad Sela (for PhD)

Tal Klingbel (for PhD)

Adi Semo (for MSc)

Noa Shkuri (for MSc)

Dr. Ainur Imangalaev

Dr. Sai Sagiri

Dr. Ilya Shlar

Dr. Alex Laskavi

Previous members

Dr. Eugene Khaskin

Dr. Tania Fadida

Dr. Zhaojun Bun

Dr. Pankaj Rastorgi

Dr. Yonit Boguslavski

Dr. Miri Klein

Dr. Anat Phylosoff

Dr. Hadar Arnon-Rips

Dr. Roi Rutenberg

Dr. Stella Kiel

Leilah Saidi 

Gilad Goldin 

Elad Matot 

Yana Zaicev

Aviva Buslovich

Adi Selilat

Shani Kehilla

Shani Danino

Rehyt Cohen

Viki Bar

Shiran Gabai

Our research

1) Natural polymers-based  systems for delivery and controlled release of active agents

We develop new approaches for modification of natural polymers aiming a formation of assembled structures and nanostructures, which are further implemented for controlled delivery of active agents, such as plant nutrients and biostimulants, signal molecules, protectants and antimicrobials, vitamins, medicines and nutraceuticals.

As a first approach we utilize covalent linkage of modifying moieties that induce biopolymers' self-assembly and result in size tunable amphiphilic structures capable for active agents' delivery. The external trigger stimuli lead to a controlled release of the active agents.

We also utilize host-guest interactions to incorporate active agents in natural polymers-based matrices. In this approach oligosaccharides are used as hosting moiety. The resulted nanosized biopolymer matrices benefit good physical and mechanical properties, high active agent content, prolonged release ability and biological activity.

Our third approach is a formation of bulk, micro- and nano- gels with controlled enacpsulation and release ability and capability of selective delivery of specified active agents. 

 2) Active edible coatings and packages to enhance quality and storability of food and agricultural products

Edible coatings and packages protect agricultural produce from physiological and microbial damage, improve appearance and respond to consumer demand for a more natural food. Our innovation in this area is the utilization of nanotechnologies and Layer-by-Layer approaches to control the coating and package properties. We utilize nanotechnologies to encapsulate antimicrobials, nutraceutics and aroma compounds into package films and coatings. Nanoparticles and nanoemulsions protect agents and allow their delivery and controlled release. In addition, nano-scale systems introduced into the natural film or coatings improve their mechanical and physical properties.

3) Contact-active antimicrobial surfaces and packages

The contact active approach involves durable (usually covalent) attachment of an antimicrobial agent to the material surface. Being surface linked, the antimicrobial agent is not consumed or released, offering an important advantage in terms of human and environmental safety. In addition, the material can be reused contributing to sustainability. Our goal is the development of synthetically simple and general strategies for the attachment of antimicrobial agents to packaging materials and surfaces that are relevant to the food industry

Publications
1. Poverenov, E., Gandelman, M., Shimon, LJW, Rozenberg, H., Ben-David, Y., Milstein, D. (2004). Nucleophilic de-coordination and electrophilic regeneration of hemilabile pincer-type complexes: Formation of anionic dialkyl, diaryl, and dihydride Pt(II) complexes bearing no stabilizing ?-acceptors.
Chem. A Eur. J. 10, 4673-4684.
IF 5.8; Category: Chemistry Multidisciplinary; Rank 18/152, Q1.

2. Poverenov, E., Gandelman, M., Shimon, LJW, Rozenberg, H., Ben-David, Y., Milstein, D. (2005).
Pincer "hemilabile" effect. PCN platinum(II) complexes with different amine "arm length".
Organometallics, 24, 1082-1090.
IF 4.2; Category: Chemistry Inorganic; Rank 6/44, Q1

3. Poverenov, E. Leitus, G., Shimon, LJW, Milstein, D. (2005).
C-Metalated diazoalkane complexes of platinum based on PCP-and PCN-type ligands.
Organometallics 24, 5937-5944.
IF 4.2; Category: Chemistry Inorganic; Rank 6/44, Q1.

4. Gandelman, M., Naing, K. , Rybtchinski, B., Poverenov, E., Ben-David, Y., Ashkenazi, N., Gauvin, RM., Milstein, D. (2005).
A general method for preparation of metal carbenes via solution- and polymer-based approaches.
J. Am. Chem. Soc. 127, 15265-15272.
IF 10.7; Category: Chemistry Multidisciplinary; Rank 11/152, Q1.

5. Poverenov, E., Leitus, G., Milstein, D. (2006).
Synthesis and reactivity of the methylene arenium form of a benzyl cation, stabilized by complexation.
J. Am. Chem. Soc. 128, 16450-16451.
IF 10.7; Category: Chemistry Multidisciplinary; Rank 11/152, Q1.

6. Poverenov, E., Milstein, D. (2007).
Formation of transition metal carbenes using haloalkylzinc reagents.
Chem. Comm. 30, 3189-3191.
IF 6.4; Category: Chemistry Multidisciplinary; Rank 17/152, Q1.

7. Poverenov, E., Shimon, LJW, Milstein, D. (2007).
Quinone methide generation based on a cis-(N,N) platinum complex.
Organometallics 26, 2178-2182.
IF 4.2; Chemistry Inorganic; Rank 6/44, Q1.

8. Schwartsburd, L., Poverenov, E. Shimon, LJW., Milstein, D (2007).
Naphthyl-based PCP platinum complexes. Nucleophilic activation of coordinated CO and synthesis of a Pt(II) formyl complex.
Organometallics 26, 2931-2936.
IF 4.2; Category: Chemistry Inorganic; Rank 6/44, Q1.

9. Vuzman, D., Poverenov, E., Diskin-posner, Y., Leitus, G., Shimon, LJW, Milstein, D. (2007).
Reactivity and stability of platinum (II) formyl complexes based on PCP-type ligands. The
significance of sterics.
Dalton Trans. 48, 5692-5700.
IF 3.8; Category: Chemistry Inorg; Rank 7/44, Q1.

10. Vuzman, D., Poverenov, E., Shimon, LJW, Diskin-Posner, Y., Milstein, D (2008). Cationic, neutral, and anionic platinum(II) complexes based on an electron-rich PNN ligand. New models of reactivity based on pincer hemilability and dearomatization.
Organometallics 27, 2627-2634.
IF 4.2; Category: Chemistry Inorganic; Rank 6/44, Q1.

11. Poverenov, E., Efremenko, I., Frenkel, A., Ben-David, Y., Shimon, LJW, Leitus, G., Martin, JML, Konstantinovsky, L., Milstein, D. (2008).
Evidence for a terminal Pt (iv)-oxo complex exhibiting diverse reactivity.
Nature 455, 1093-1096.
IF 36.1; Category: Multidisciplinary; Rank 1/59, Q1.

12. Poverenov, E., Iron, MA, Gandelman, M., Ben-David, Y., Milstein, D. (2010).
Anionic d(8) Alkyl Hydrides - Selective formation and reactivity of cis-Pt(II) methyl hydride.
Eur. J. Inorg. Chem. 13, 1991-1999.
IF 3.1; Category: Chemistry Inorg; Rank 11/44, Q1.

13. Poverenov, E., Li, M., Bitler, A., Bendikov, M. (2010).
Major effect of electropolymerization solvent on morphology and electrochromic properties of PEDOT films.
Chem. Mater. 22, 4019-4025.
IF 8.2; Category: Material Science; Rank 16/225, Q1.

14. Poverenov, E., Sheynin, Y., Zamochshik, N., Patra, A., Leitus, G, Perepichka, IF, Bendikov, M. (2012).
Flat conjugated polymers combining a relatively low HOMO energy level and band gap: Polyselenophenes versus polythiophenes.
J. Mater, Chem. 22, 14645-14655.
IF 6.1; Category: Material Science; Rank 12/225, Q1.

15. Poverenov, E., Efremenko, I., Leitus , G., Martin, JML, Milstein, D. (2013).
Benzyl cation stabilized by metal complexation. Relative stability of coordinated methylene arenium, ?-benzylic and ?-benzylic structures.
Organometallics 32, 4813-4819.
IF 4.2; Category: Chemistry Inorganic; Rank 6/44, Q1.

16. Poverenov, E., Milstein, D. (2013).
Noninnocent behavior of PCP and PCN pincer ligands of late metal complexes.
Organometallic pincer chemistry.
Top. Organomet. Chem. 40, 21-47.
IF 6.3; Category: Chemistry Organic; Rank 5/57, Q1.

17. Poverenov, E., Granit, R. Gabai , S. (2013).
Encapsulation and controlled release of propionic acid utilizing biodegradable active films based on natural polymers.
Eur. Food Res. Technol. 237, 19-26.
IF 2.4; Category: Food Sci. Techn.; Rank 62/133, Q2.

18. Poverenov, E.,** Shemesh, M., Gulino, A., Zakin, V., Yefremov, T. S and Granit, R. S (2013).
Durable contact active antimicrobial materials formed by a one-step covalent modification of polyvinyl alcohol, cellulose and glass surfaces.
Colloids and Surfaces B. 112, 356.
IF 4.4; Category: Biophysics; Rank 13/72, Q1.

19. Arnon , H., S Porat, R., Zaitsev , Y., S Poverenov, E.** (2014).
Effects of carboxymethyl cellulose and chitosan bilayer edible coating on postharvest quality of citrus fruit.
Postharvest Biol. Technol. 87, 21-26.
IF 4.3; Category: Food Science and Technology; Rank 26/133, Q1.

20. Poverenov, E.,** Danino , S., S Horev, B., Granit, R., S Vinokur, Y., Rodov, V. (2014).
Layer-by-Layer electrostatic deposition of edible coating on fresh cut melon model: anticipated and unexpected effects of alginate-chitosan combination.
Food Bioprocess Techn. 7, 1424-1432.
IF 3.4; Category: Food Science and Technology; Rank 30/133, Q1.

21. Poverenov, E.,** Zamochshik, N., Patra, A., Ridelman, I., Bendikov, M. (2014).
Unusual doping of donor-acceptor-type conjugated polymers using lewis acids.
In memory of Prof. M. Bendikov
J. Am. Chem. Soc. 136, 5138-5149.
IF 14.6; Category: Chemistry Multidisciplinary; Rank 11/152, Q1.

22. Poverenov, E.,** Zaitsev , Y., S Arnon , H., S Granit, R., S Perzelan, Y., Fallik, E. (2014).
Effects of a composite chitosan-gelatin edible coating on postharvest quality and storability of red bell peppers.
Postharvest Biol. Technol. 96, 106-109.
IF 4.3; Category: Food Science and Technology; Rank 26/133, Q1.

23. Poverenov, E.,** Rutenberg , R., S Danino , S., Horev, B., Rodov, V. (2014).
Gelatin-chitosan composite films and edible coatings to enhance the quality of food products: Layer by Layer vs. blended formulations.
Food Bioprocess Techn. 214, 3319-3327.
IF 3.4; Category: Food Science and Technology; Rank 30/133, Q1.

24. FadidaS, T., Kroupitski, Y., Peiper, UM, Bendikov, T., Sela, S., Poverenov, E** (2014).
Air-ozonolysis to generate contact active antimicrobial surfaces: Activation of polyethylene and polystyrene followed by covalent graft of quaternary ammonium salts.
Colloids and Surfaces B. 122, 294-300.
IF 4.4; Category: Biophysics; Rank 13/72, Q1.

25. Arnon S, H., Granit, R., S Porat, R., Poverenov, E.** (2015).
Development of polysaccharides-based edible coatings for citrus fruits: a Layer-by-Layer approach. Food Chem., 166, 465-472.
IF 6.3; Category: Food Science and Technology; Rank 7/133, Q1

26. Shlar, I., Poverenov, E., Vinokur, Y., Horev, B., Droby, S., Rodov, V (2015).
High-throughput screening of nanoparticle-stabilizing ligands: application to preparing antimicrobial curcumin nanoparticles by antisolvent precipitation.
NanoMicro Letters, 7, 68-79.
IF 12.2; Category: NanoScience and Nanotechnology; Rank 11/103.

27. FadidaS, T., Selilat-Weiss , A., S Poverenov, E** (2015)
N-hexylimine-chitosan, a biodegradable and covalently stabilized source of volatile, antimicrobial hexanal. Next generation controlled-release system.
Food Hydrocolloids, 48, 213-219.
I.F. 7.1; Category: Chemistry Applied; Rank 4/71, Q1.

28. Khaskin, E.,S Fadida, T., S Kroupitski, Y., Shemesh, M., Gulini, A., Poverenov, E.** (2015).
A contact active bactericidial stainless steel via a sustainable process utilizing electrodeposition and covalent attachment in water.
Green Chem., 17, 2344-2347.
I.F. 9.4; Category: Chemistry, Multidisciplinary; Rank 21/171, Q1.

29. Rutenberg, R.,S Leytus, G., Fallik, E., Poverenov, E.** (2016).
Discovery of a non-classic host guest complexation mode in a b-cyclodextrin/propionic acid model.
Chem.Commun., 52, 2565-2568.
IF 6.0; Category: Chemistry, Multidisciplinary; Rank 28/171, Q1.

30. Rutenberg, R.,S Bernstein, S., Paster, N., Fallik, E., Poverenov, E.** (2016).
Antimicrobial Films Based on Cellulose-Derived Hydrocolloids. A Synergetic Effect of Host-Guest Interactions on Quality and Functionality.
Colloids and Surfaces B, 137, 138-145.
IF 4.4; Category: Biophysics; Rank 13/72, Q1.

31. Buslovich, A. S Horev, B. Rodov, V. Gedanken A. and Poverenov E.** (2017).
One-step surface grafting of organic nanoparticles: in situ deposition of antimicrobial agents vanillin and chitosan on polyethylene packaging films.
J. Mater. Chem. B, 5, 2655-2661.
IF 5.1; Category: Materials Science, Biomaterials; Rank 8/33, Q1.

32. Bilbao-Sainz, C., Chiou, B.-S., Williams, T., Wood, D., Du, W.-X., Sedej, I.; Ban, Z., Vinokur, Y., Rodov, V., Poverenov, E. and McHugh, T. (2017).
Vitamin D-fortified chitosan films from mushroom waste.
Carbohydrate Polym. 16, 97-104.
IF 7.2; Category: Chemistry Applied; Rank 2/71, Q1.

33. Lu, H., Ban, Z., Wang, K., Li, D. Li, D., Poverenov, E., Li, L., Luo, Z. (2017).
Aroma volatiles, sensory, and chemical attributes of strawberry (Fragaria×ananassa Duch.) achenes and receptacle.
Int. J. Food Sci. Techn. 52, 2614-2622.
I.F. 2.3, Category: Food Science and Technology, Rank 41/133, Q2.

34. Rutenberg, R, S Bernstein, S. Fallik, E., Paster, N., Poverenov, E.** (2018).
The improvement of propionic acid safety and use during the preservation of stored grains.
Crop Protection.110, 191-917.
IF 2.2; Category: Agronomy; Rank 21/87, Q1.

35. Golden, G., S Quinna, E., Shaaya, E., Kostyukovsky, M., Poverenov, E.** (2018).
Coarse and nano emulsions for effective delivery of natural pest control agent pulegone for stored grain protection.
Pest Management Sci.74, 820-827.
I.F. 3.8, Category: Agronomy; Rank 8/87, Q1.

36. Yana, J., Ban, Z., Lu, H., Li, D., Poverenov, E., Li, L., Luo, Z (2018).
The aroma volatile repertoire in strawberry fruit: a review.
J. Sci. Food Agr. 98, 4395-4402.
IF 2.5; Category: Agriculture, Multidisciplinar; Rank 8/56, Q1.

37. Buslovich, A., S Horev, B., Shebis, Y., S Rodov, V., Gedanken, A., Poverenov, E.** (2018)
A facile method for the deposition of volatile natural compound-based nanoparticles on biodegradable polymer surfaces.
J. Mater. Chem. B, 6, 2240-2249.
IF 5.1; Category: Materials Science, Biomaterials; Rank 8/33, Q1.

38. Ban, Z.,S Horev, B, Rutenberg, R, Danay, O, Bilbao, C, McHugh, T, Rodov, V., Poverenov, E** (2018).
Efficient production of fungal chitosan utilizing an advanced freeze-thawing method; quality and activity studies.
Food Hydrocolloids, 81, 380-388.
I.F. 6.3; Category: Chemistry Applied; Rank 4/71, Q1.

39. Bilbao-Sainz, C., Chiou, B.-S., Punotai, K., Olson, D., Williams, T.; Wood, D., Rodov, V.,
Poverenov, E., McHugh. T. (2018).
Layer-by-layer alginate and fungal chitosan based edible coatings applied to fruit bars.
J. Food Science. 83, 1880-1887.
I.F. 2.3; Category: Food Science and Technology; Rank 54/133, Q2.

40. Boguslavcki, Y., S Shemesh, M., Friedlander, A., Rutenberg, R., Molad Filossof, A., Buslovich, A., Poverenov, E.** (2018).
Eliminating the Need for Biocidal Agents in Anti-Biofouling Polymers by Applying Grafted Nanosilica Instead.
ACS Omega, 3, 12437-12445
IF; 2.9 Category: Chemistry Multidisciplinary; Rank 81/177, Q2.

41. Poverenov, E.,** Arnon,S H. Zaicev, S Y. Bar, S V. Danay, O. Horev, B., Bilbao-Sainz, C., McHugh, T. Rodov, V. (2018).
Potential of chitosan from mushroom waste to enhance quality and storability of fresh-cut melons. Food Chemistry, 263, 233-241.
IF 6.3; Category: Food Science and Technology; Rank 6/139, Q1

42. Rutenberg, R,S Golden, Cohen, Y., G., Kleiman, M., Poverenov, E.** (2018).
Investigation of The Substituent Effect in Modified Nature-Sourced Polymers; Rational Side Chain Engineering to Control Yield, Design, and Properties
ACS Omega. 3, 12841-12850.
IF; 2.9 Category: Chemistry Multidisciplinary; Rank 81/177, Q2.

43. Rutenberg, R.,S Galaktionova, D., Golden, G., Cohen, Y., Levi-Kalisman, Y., Cohen, G., Král, P., Poverenov, E.** (2018)
Omniphilic Polysaccharide-Based Nanocarriers for a Modular Molecular Delivery in a Broad Range of Bio-Systems.
ACS Applied Materials & Interfaces. 10, 36711-36720.
IF; 8.8; Category: NanoScience and Nanotechnology; Rank 18/103, Q1.

44. Arnon-Rips, H., S Porat, R., Poverenov, E.** (2019).
Enhancement of agricultural produce quality and storability using citral-based edible coatings; the valuable effect of nano-emulsification in a solid-state delivery.
Food Chemistry. 277, 205-212.
IF 6.3; Category: Food Science and Technology; Rank 6/139, Q1.

45. Shebis, Y., Bhooshan Kumar, V., Gedanken, A., Poverenov, E. ** (2020)
Cooperative crystallization effect in the formation of sonochemically grafted active materials based on polysaccharides.
Colloids and Surfaces B, 190, 110931.
IF 4.4; Category: Biophysics; Rank 13/72, Q1.

46. Hadar Arnon-Rips, H., Sabag, A., Tepper-Bamnolker, P., Chalupovich, D., Levi-Kalisman, Y., Eshel, D., Porat, R., Poverenov, E. ** (2020)
Effective suppression of potato tuber sprouting using polysaccharide-based emulsified films for prolonged release of citral.
Food Hydrocolloids, 103, 105644.
I.F. 7.1; Category: Chemistry Applied; Rank 4/71, Q1.

47. Cohen, Y., Rutenberg, R., Cohen, G., Veltman, B., Gvirtz, R., Fallik, E., Danino, D., Eltzov, E., Poverenov, E. ** (2020)
Aminated polysaccharide-based nanoassemblies as stable biocompatible vehicles enabling to cross biological barriers. An effective transdermal delivery of Diclofenac medicine.
ACS Appl. Bio Mater. 3, 2209-2217.
IF; new journal in ACS Publications Category: Chemistry Multidisciplinary.

48. Nasonova, A., Cohen, Y., Poverenov, E., Borisover, M.(2020)
Binding interactions of salicylic acid with chitosan and its N-alkylated derivative in solutions: an equilibrium dialysis study.
Colloids and Surfaces A, 603, 125202.
IF 4.0; Category: Biophysics; Rank 13/72, Q1.

49. Arnon-Rips, H., Cohen, Y., Saidi, L., Porat, R., Poverenov, E.** (2021).
Covalent linkage of bioactive volatiles to a polysaccharide support as a potential approach for preparing active edible coatings and delivery systems for food products.
Food Chemistry, 338, 127822.
IF 6.3; Category: Food Science and Technology; Rank 6/139, Q1

50. Gaur, R. Z., Khoury, O. Zohar, M., Poverenov, E., Darzi, R., Laor, Y., Rosmanik, R. (2020)
Hydrothermal Carbonization of Sewage Sludge Coupled with Anaerobic Digestion: Integrated Approach for Sludge Management and Energy Recycling.
Energy Convers. Manag., 224, 113353.
I.F. 8.2; Category: Energy and Fuel Science; Rank 11/112, Q1.

51. Huang, R., Vaze, N., Soorneedi, A. Moore, M.D., Luo, Y., Poverenov, E., Rodov, V. Demokritou, P. (2021).
A Novel Antimicrobial Technology to Enhance Food Safety and Quality of Leafy Vegetables using Engineered Water Nanostructures.
Environmental Science: Nano, DOI: 10.1039/D0EN00814A
IF 7.7; Category: NanoScience and Nanotechnology; Rank 21/103, Q1.

52. Saidi, L., Duanis-Assaf, D., Galsarker, O., Maurer, D., Alkan, N., Poverenov, E.** (2021)
Elicitation of fruit defense response by active edible coatings embedded with phenylalanine to improve quality and storability of avocado fruit.
Postharvest Biol. Technol. 174, 111442.
IF 4.3; Category: Food Science and Technology; Rank 26/133, Q1.

 Books and Invited Reviews

1. Arnon-Rips, H.S and Poverenov, E.** (2018).
Layer-by-Layer Edible Coatings to Improve Quality and Storability of Food Products.
Trends in Food Sci. Technol. 75, 81-92.
I.F. 11.1., Category: Food Science and Technology, Rank 1/139, Q1.

2. Poverenov, E.** and Klein M. (2018).
Formation of contact active antimicrobial surfaces by covalent grafting of quaternary ammonium compounds .
Colloids and Surfaces B., 169, 195-205.
IF 4.4; Category: Biophysics; Rank 13/72, Q1.

3. Klein, M., Poverenov, E.** (2020). Natural biopolymer?based hydrogels for use in food and agriculture.
Science of Food and Agriculture. 100, 2337.
IF 2.5; Category: Food Science and Technology; Rank 7/133, Q1.

53. van Houten, F., Wertheim R., Ayali, A., Poverenov, E., Mechraz, G., Eckert, U., Rentzsch, H., Dani, I., Willocx, M. Duflou, J.R. (2021). Bio-based design methodologies for products, processes, machine tools and production systems.
CIRP Journal of Manufacturing Science and Technology, 32, 46-60.
IF 3.0. Technology Multidisciplinary

 Book Chapters

1. Poverenov, E. and Milstein, D. (2009).
Quinone methide stabilization by metal complexation.
In Reactive Intermediates Chemistry and Biology. (S.E. Rokita ed.)
Publisher John Wiley & Sons, New Jersey, USA.
Invited Chapter

2. Arnon-Rips, H.,S Porat, R., Poverenov, E.** (2016).
Biopolymers-embeded nanoemulsions and other nanotechnological approaches for safety, quality and storability enhancement of food products: active edible coatings and films. In Emulsions. (A.M. Grumezescu, ed.), Publisher Elsevier Academic Press. Cambridge, Massachusetts, USA.
Invited Chapter