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הנהלה מרכז מידע - ספריה תלמידי מחקר יחידה עסקית דוברות מכוני מחקר אודות
שלח באימייל הדפס
מיכה רון, 'פרופ  :שם
חקר בעלי חייםהמחלקה לחקר בקר וצאן :מחלקה/יחידה
08-9484428 :טלפון
050-6220428 :סלולרי
08-9470587 :פקס
  micha.ron@mail.huji.ac.il :דוא"ל
Department of Quantitative and Molecular Genetics
Institute of Animal Science
Agricultural Research Organization,
The Volcani Center,
Institute of Animal Science, Agricultural Research Organization (ARO), Rishon LeTsiyon, P.O.B 15159, 7528809, Israel

.גנטיקה והשבחה של בקר ודגים. שימור מיני חיות הבר על ידי אפיון גנומי.

תחומי עניין / תאור תפקיד
חקר המנגנון הגנטי של קביעת מין באמנונים ויצירת אוכלוסיות כל זכריות, סלקציה גנומית ברמת ה-דנא בבקר לחלב. פיתוח סמנים גנטיים ומפות תאחיזה לדגים דקר המכמורת ובורי. איתור הגנים לקביעת זוויג בדגים בורי ואמנון ליצירת אוכלוסיות כל -נקביות ו -זכריות, בהתאמה. שימור מיני חיות הבר על ידי אפיון גנומי באמצעות דנ"א ברקודינג.

Research Interests

Study of the genetic mechanism of sex determination in tilapia and creation of all-male populations, Genomic selection at the DNA level in cattle. Development of genetic markers and linkage maps for the White Grouper and Buri fish. Study of sex determination in Buri and Gupi for creation of all -female and -male populations, respectively.

Recent Publications (out of 116)

  • Palti, Y., A. Shirak, A. Cnaani, G. Hulata, R.R. Avtalion, and M. Ron (2002). Detection of genes with deleterious alleles in an inbred line of tilapia (Oreochromis aureus). Aquaculture 206 (3-4): 151-164.
  • Cnaani A., Ron M., Lee B. -Y., Hulata G., Kocher T. D. and Seroussi E. (2002). Mapping the Transferrin gene in tilapia. Anim. Genet. 33: 78-80.
  • Cnaani A., Ron M., Hulata G. and Seroussi E. (2002). Fishing in silico: searching for tilapia genes using sequences of microsatellites DNA markers. Anim. Genet. 33; 474-476.
  • Shiraq A., Palti Y., Cnaani A., Korol A., Hulata G., Ron M. and Avtalion R. (2002). Association between loci with deleterious alleles and distorted sex ratios in an inbred line of tilapia (Oreochromis aureus). J. of Heredity 93: 270-276.
  • Cnaani A., Hallerman, E. M., Ron, M., Weller, J. I., Indelman, M., Kashi, Y., Gall, G. A. E. and Hulata, G. (2003). Detection of a chromosomal region with two quantitative trait loci, affecting cold tolerance and fish size, in an F2 tilapia hybrid. Aquaculture 223; 117-128.
  • Cnaani, A., Lee, B.-Y., Ron, M., Hulata, G., Kocher, T.D., Seroussi, E. (2003). Linkage mapping of major histocompatibilty complex class I loci in tilapia (Oreochromis spp.). Anim. Genet. 34; 390-391.
  • Cnaani A., Zilberman N., Tinman S., Hulata G. and Ron M. (2004). Genome-scan analysis for quantitative trait loci in an F2 tilapia hybrid. Molecular Genetics and Genomics 272:162-172.
  • Cnaani A., Tinman S., Avidar Y., Ron M. and Hulata G. (2004). Comparative study of biochemical parameters in response to stress in Oreochromis aureus, O. mossambicus and two strains of O. niloticus Aquaculture Research 35: 1434-1440.
  • Shirak A., Bendersky A., Weller J.I., Hulata G., Ron M., and Avtalion R.R. (2006) Altered self-erythrocyte recognition and destruction in an inbred line of tilapia (Oreochromis aureus). Immunology 176(1):390-4
  • Shirak A., Seroussi E., Cnaani A., Howe, A.E., Domokhovsky, R., Zilberman, N., Kocher, T.D., Hulata, G. and Ron M. (2006) Amh and Dmrta2 genes map to Tilapia (Oreochromis spp.) linkage group 23 within QTL regions for sex determination . Genetics 174:1573-81
  • Zilberman N., Reikhav S., Hulata G., and Ron M (2006). High-throughput genomic DNA extraction protocol from Tilapia fin tissue. Aquaculture 255: 597-599.
  • Cnaani A., Lee B-Y., Zilberman N., Ozouf-Costaz C., Hulata G., Ron M., D'Hont A., Baroiller J-F., D'Cotta H., Penman D.J., Tomasino E., Coutanceau J-P., Pepey E., Shirak A., Kocher, TD. (2008). Heredity of sex determination in Tilapiine species. Sex Dev. 2:43-54. 
  • Shirak  A., Lee B.-Y., Golik M., Howe A., Kocher T.D., Hulata, G., Ron M. and Seroussi E. (2008). Copy number variation of lipocalin family genes for Male-specific proteins in tilapia and its association with gender. J. of Heredity 1-11.
  • Shirak A., Cohen-Zinder M., Melon R., Seroussi, E., Ron M. and Hulata G. (2009). DNA barcoding of Israeli endemic and introduced cichlids.   Israeli Journal of Aquaculture - Bamidgeh 61(2):83-88.
  • Shirak A., Grabherr M., Di Palma F., Lindblad-Toh K. Hulata G., Ron M. Kocher TD. and Seroussi E. (2009) Identification of repetitive elements in the genome of Oreochromis niloticus: Tilapia repeat-masker. Marine Biotechnology 12(2):121-5. 
  • Eshel O., Shirak A., Weller J.I., Slossman T. Hulata G.  and Ron M. (2011)  Fine mapping of quantitative trait locus for sex-determination on linkage group 23 in Nile tilapia (Oreochromis niloticus). Anim. Genet. 42(2):225-6.

  • Velan A., Hulata G., Ron M., and Cnaani A. (2011) Comparative time-course study on pituitary and branchial response to salinity challenge in Mozambique tilapia (Oreochromis mossambicus) and Nile tilapia (O. niloticus). Fish Physiology and Biochemistry 37:863-873.

  • Eshel O., Shirak A., Weller J.I., Slossman T., Hulata G., and Ron M. (2012)   Linkage and physical mapping of sex region on LG23 of Nile Tilapia (Oreochromis niloticus).Genes| Genomes| Genetics 2:35-42

  • Shirak A., Palti Y., Bern O., Kocher T., Gootwine E., Seroussi E., Hulata G., Ron M. and R.R. Avtalion (2012) A deleterious effect associated with UNH159 is attenuated in twin embryos of an inbred line of tilapia (Oreochromis aureus) J. Fish Biol. Accepted.

  • Shirak A., Reicher S., Uliel S., Mehlman T., Shainskaya A., Ron M. and Seroussi E. (2012) Gender and sexual behavior modulate the composition of serum lipocalins in Nile tilapia (Oreochromis niloticus). Gene 1;504(1):22-30.

  • Shirak A., Barkai O., Lernau O., Kahanov Y., Seroussi E. and Ron M.  (2012) DNA barcoding analysis of fish bones from a shipwreck found at Dor, Israel.  Journal of Aquaculture - Bamidgeh (In press).

  • Shirak A., Palti Y., Bern O., Kocher T., Gootwine E., Seroussi E., Hulata G., Ron M. and R.R. Avtalion (2013.) A deleterious effect associated with UNH159 is attenuated in twin embryos of an inbred line of tilapia (Oreochromis aureus) J. Fish Biol. 82(1):42-53.

  • Brawand D. et al. (2014) The genomic substrate for adaptive radiation: genomes of five African cichlid fish (total of 74 co-authors including Ron M.) Nature 18;513(7518):375-81.

  • Dor L., Shirak A., Gorshkov S., Ron M., and Hulata G. (2014) Development of genetic markers for the white grouper (Epinephelus aeneusAquaculture 420–421 (Suppl 1): S104–S110. 

  • Dor L., Shirak, A. Gorshkov S., Band M.R., Korol AB, Ronin Y., Curzon A., Hulata G., Seroussi E., and Ron M. (2014) Construction of a microsatellites-based linkage map for the white grouper (Epinephelus aeneus). Genes| Genomes| Genetics 5;4(8):1455-64.

  • Eshel O. , A. Shirak, L. Dor, M. Band, T. Zak, M. Gordon, V. Caspi, E. Feldmesser, J.I. Weller, E. Seroussi, G. Hulata and M. Ron (2014) Identification of male-specific amh duplication, genes and microRNAs differentially expressed between genders at early embryonic development of Nile tilapia (Oreochromis niloticus). BMC Genomics 15:774-.

  • Velan A., Hulata G., Ron M., Slosman T., and Cnaani A. (2015) Association between polymorphism in the Prolactin I promoter and growth of tilapia in saline-water. Aquaculture Reports 1:5-9.

  • Shirak A., Dor L., Seroussi E., Ron M., Hulata G. and Golani D. (2016) DNA barcoding of Mediterranean fish species. Medit. Mar. Sci. 17/2 459-466.
  • Dor L., Shirak A., Rosenfeld H., Meiri I., Band M.R., Korol A., Yefim R., Seroussi E., and Ron M. (2016) Mapping of the sex determination region of Flathead grey mullet (Mugil cephalus). Animal Genetics 47(6):698-707.
  • Dor L., A. Shirak, H. Rosenfeld, I. Meiri-Ashkenazi, G. Rubinstein, E. Seroussi, J.I. Weller and Ron M. (2018) Genetic stock identification of the Flathead grey mullet (Mugil cephalus) in Sea of Galilee (Israel) based on parent-offspring relationship. Journal of Aquaculture - Bamidgeh 6: 873-78.

    • Shirak A., Zak T., Dor L Benet-Perlberg A., Weller JI., Ron M., and Seroussi E. (2018) Quantitative trait loci on LGs 9 and 14 affect the reproductive interaction between two Oreochromis species, O. niloticus and O. aureus. J. of Heredity 122: 341-353
    • Curzon A.Y., Shirak A., Dor L., Zak T., Perelberg A., Seroussi E. and M. Ron (2019) The origin of the Thai-Chitralada Tilapia strain of Oreochromis niloticus using DNA barcoding and microsatellites analysis. Journal of Aquaculture - Bamidgeh 71: 1-7. http://hdl.handle.net/10524/62895.
    • Dor L., Shirak A., Kohn Y., Gur T., Weller J.I., Zilberg D., Seroussi E. and M. Ron (2019) Mapping of the sex determining region on linkage group 12 of Guppy (Poecilia reticulate). Genes| Genomes| Genetics 9: 3867-3875.
    • Curzon A.Y., Shirak A., Dor L., Zak T., Perelberg A., Seroussi E. and M. Ron (2020) A duplication in the Anti Müllerian hormone is associated with genetic sex determination of different Oreochromis niloticus strains. J. of Heredity (In press).
    • Dor, L., Shirak, A., Curzon, Rosenfeld, H., Ashkenazi, IM., Nixon, O., Seroussi, E., Weller, JI., and Ron, M. (2020)
       Preferential mapping of sex-biased differentially-expressed genes of larvae to the sex-determining region of flathead grey mullet (Mugil cephalus). Frontiers in Genetics 11: 839-850.
    • Curzon A.Y., A. Shirak, H. Rosenfeld, I. Meiri-Ashkenazi, M. Ron and E. Seroussi (2021) A novel c.1759T>G variant in the vertebrate FSHR orthologous gene is associated with sex determination in the flathead grey mullet (Mugil cephalus).Genes| Genomes| Genetics G3 (Bethesda) 9: 11(2)
    • Curzon A.Y, Shirak A, Zak T, Dor L, Benet-Perlberg A, Naor A, Low-Tanne S.I, Sharkawi H, Ron M and Seroussi E. (2021) All-male production by marker-assisted selection for sex determining loci of admixed Oreochromis niloticus and O. aureus stocks. Animal Genetics (In press).
    • Seroussi E., Ron M. and Kedra D. (2002) ShiftDetector: Detection of frame shift mutations. J. of BioInformatics 18:1137-8.
    • Weller J.I., Weller H., Kliger D. and Ron M. (2002) Estimation of quantitative trait locus allele frequency via a modified granddaughter design. Genetics 162: 841-849.
    • Ron M., Domochovsky, R., Golik, M., Seroussi, E., Ezra, E., Shturman, C., and Weller, J. I. (2003) Analysis of vaginal swabs for paternity testing and marker-assisted selection in cattle. J. Dairy Sci. 86; 1789-1796.
    • Weller, J. I., Golik, M., Seroussi, E., Ezra, E., and Ron, M. (2003) Population-wide analysis of a QTL affecting milk-fat production in the Israeli Holstein population. J. Dairy Sci. 86(6):2219-27.
    • Ashwell, M. S., Heyen, D. W., Sonstegard, T. S., Van Tassell, C. P., Da, Y., Van Raden, P. M., Ron, M., Weller, J. I. and Lewin, H. A. (2004). Detection of quantitative trait loci affecting female fertility and milk production in ten Dairy Bull DNA Repository families. J. Dairy Sci. 87(2):468-75.
    • Plis-Finarov A., Hudson H., Roe B., Ron M., E. Seroussi (2004). Mapping of the GATA4, NEIL2, FDFT1 genes and CTSB-associated microsatellites to the centromeric region of BTA8. Anim. Genet. 35, 154-155
    • Ron M., Feldmesser, E., Golik, M., Tager-Cohen, I., Kliger, D., Reiss, V., Domochovsky, R., Alus, O., Seroussi, E., Ezra, E., and Weller, J. I. (2004) A complete genome scan of the Israeli Holstein population for quantitative trait loci by a daughter design. J. Dairy Sci. 87(2):476-90.
    • Cohen M., Reichenstein M., Everts-van der Wind A., Heon-Lee J., Shani M., Lewin H.A., Weller J.I., Ron M., and Seroussi E. (2004). Cloning and characterization of FAM13A1- a gene near a milk protein QTL on BTA6: evidence for population-wide linkage-disequilibrium in Israeli Holsteins. Genomics 84(2): 374-83
    • Weller, J. I., Feldmesser, E., Golik, M. Tager-Cohen I., Domochovsky R., Alus O., Ezra, E., and Ron, M. (2004) Factors affecting incorrect paternity assignment in the Israeli Holstein population J. Dairy Sci. 87 (8): 2627-40
    • Ron M., Tager-Cohen I, Feldmesser E., Ezra E.,. Kalay D., Roe B., Seroussi E., and Weller J.I. (2004) Bovine umbilical hernia maps to the centromeric end of Bos taurus autosome 8. Animal Genetics 35(6): 431-7.
    • Cohen-Zinder M., Seroussi E., Larkin D.M., Loor J.I., Everts-van der Wind A., Huon-Lee J., Drackley J.K., Band M.R., Shani M., Lewin H.A., Weller J.I., and Ron M. (2005) Identification of a missense mutation in the bovine ABCG2 gene with a major effect on the QTL on chromosome 6 affecting milk yield and composition in Holstein cattle. Genome Research 15: 936-944
    • Ashwell A.S., Heyen D.H., Sonstegard T.S., Van Tassell C.P., Ron M., Weller J.I. and Lewin H.A. (2005) Detection of quantitative trait loci influencing conformation traits and calving ease in Holstein-Friesian cattle. J. Dairy Science 88(8): 4111-4119.
    • Weller JI, Shlezinger M, and Ron M. (2005) Correcting for bias in estimation of quantitative trait loci effects. Genet Sel Evol. 37(5): 501-22.
    • Baruch E., Weller J.I., Cohen Zinder M., Ron M., and Seroussi E. (2005) Efficient inference of haplotypes from genotypes on a large animal pedigree. Genetics 172: 1757-65
    • Golik M., Cohen-Zinder M., Loor J.J., Drackley J.K., Band M.R., Lewin H.A. Weller J.I., Ron M. and E. Seroussi (2006). Accelerated expansion of group IID like phospholipase A2 genes in Bos Taurus. J. of Genomics 87: 527-33 .
    • Weller J.I., Seroussi E. and Ron M. (2006). Estimation of the number of genetic markers required for individual animal identification accounting for genotyping errors Animal Genetics 37(4): 387-9 .
    • Ron M., Cohen-Zinder M., Peter C., Weller J.I. and Erhardt G. (2006) ABCG2 Polymorphism in Bos indicus and Bos taurus Cattle Breeds. J. Dairy Sci. 89(12): 4921-4923
    • Ron M. and Weller J.I. (2007) From QTL to QTN identification in livestock "Winning by points rather than knock-out". Animal Genetics: a review 38(5): 429-39.
    • Ron M., Israeli G., Seroussi E., Weller J.I., Gregg P.J., Shani M., and Medrano J.F. (2007). Combining mouse mammary gene expression and comparative mapping for the identification of candidate genes for QTL of milk production traits in dairy cattle. BMC Genomics 8: 183.
    • Weller J.I., Reikhav S., Golik M., Domochovsky R. and Ron M. (2008). Detection and analysis of QTL affecting production and secondary traits on chromosome 7 in Israeli Holsteins. J. Dairy Sci. 91: 802-813.
    • Weller J. I., Golik M., Seroussi E., Ron M., and Ezra E. (2008) Detection of quantitative trait loci affecting twinning rate in Israeli Holsteins by the daughter design. J. Dairy Sci. 91(6): 2469-74.
    • Karniol B., Shiraq A., Baruch E., Tal A., Cahana A., Kam M., Skalski Y., Singrun C., Brem G., Weller K.I., Ron M., Seroussi E. (2009). Development of a 25-plex SNP assay for traceability in cattle. Animal Genetics 40(3): 353-6.
    • Weller J.I., Glick G., Seroussi E., and Ron M. (2010) Paternity validation and estimation of genotyping error rate for the BovineSNP50 BeadChip. Anim. Genet. 41(5):551-3.

    • Ron M., Porat B., Band M.R. and Weller J.I. (2011) Chimaerism detection in  bovine twins, triplets and quadruplets using sex chromosomes linked markers. Anim. Genet. 42(2):208-11.

    • Weller J.I.  and Ron M.  (2011) Quantitative trait nucleotide determination in the era of genomic selection. J. Dairy Sci. Invited Review, 94(3):1082-90.

    • Golik M., Glick G., Reicher S., Shiraq A., Ezra E., Zeron Y.,  Gootwine E., Ron M. , Weller J.I.  and Seroussi E. (2011) Differential expression of ruminant ZNF496 variants: Association with QTL affecting bovine milk concentration and fertility.  J. Dairy Sci. 94(4):2092-102.
    • Glick G., Shirak A., Seroussi E., Zeron Y., Ezra E., Weller JI and Ron M. (2011) Fine mapping of a QTL for fertility on BTA7 and its association with a CNV in the Israeli Holsteins. Genes| Genomes| Genetics 1:65-74..
    • Weller J. I., Ron M., Glick G., Shirak A., Zeron Y. and Ezra E. (2012). A simple method for genomic selection for moderately sized dairy cattle populations. Animal 6(2):193-202.
    • Glick G., Shirak A., Uliel S., Zeron Y., Ezra E., Seroussi E., Ron M. and Weller JI (2012)  Signatures of contemporary selection in the Israeli Holstein dairy cattle. Anim. Genet. 43 Suppl 1:45-55.
    • Lourenco D.A.L., Misztal I., Tsuruta S., Aguilar I., Ezra E., Ron M., Shirak A.,  and J. I. Weller (2013) Methods for genomic evaluation of a relatively small  dairy population and effect of genotyped cow information in multiparity analyses. J. Dairy Sci. 97(3):1742-52.
    • Seroussi E., Glick G., Shirak A., Ezra E.,  Zeron Y., Ron M. and J. I. Weller (2013) Maternity validation using sire-only BovineSNP50 BeadChip data. J. Dairy Sci44(6): 754-7
    • Weller JI., Glick G., Shirak A., Ezra E., Seroussi, E., Shemesh M., Zeron Y. and Ron M. (2014) Predictive ability of selected subsets of single nucleotide polymorphisms (SNPs) for moderately sized dairy cattle populations Animal 8(2): 208-16.  
    • Weller J. I., Ezra E. and Ron M (2017) A perspective on the future of genomic selection in dairy cattle. J. Dairy Sci. Invited Review 100:1-12.
    • Weller JI., Bickhart DM., Wiggans GR., Tooker ME., O'Connell JR., Jiang J., Ron M. and PM. VanRaden. (2018) Determination of quantitative trait variants by concordance via application of the A posteriori granddaughter design to the U.S. Holstein population. J. of Dairy Science 101(10): 9089-9107..

    Current Projects

    • Heredity of sex determination towards production of all-male population in tilapia and gupy fish, and all-female population in Buri fish
    • Development of genetic markers and maps for the White Grouper and Buri fish
    • From QTL to QTN identification in livestock
    • Genomic selection in cattle
    • DNA barcoding of fish at the Mediterranean sea
    קורות חיים  
    מעודכן בתאריך: 26/01/23 17:39
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