Publications

Poultry bone disorders

Eswarakumar VP, Monsonego-Ornan E, Pines M, Antonopoulou I, Morriss-Kay GM,  Lonai P. (2002). The IIIc alternative of Fgfr2 is a positive regulator of endochondral ossification. Development  129:3783-3793.

Tong A, Reich A., Genin O, Pines M, Monsonego-Ornan E. (2003).Expression of  chicken 75-kDa gelatinase B-like enzyme in perivascular chondrocytes suggests its role in vascularization of the growth plate. J. Bone Miner. Res. 18:1443-452.

Pines M, Hasdai A and Monsonego-Ornan E. (2005). Tibial dyschondroplasia - tools, new insights and future prospects. World's Poult. Sci. J. 61:285-297.

Yalcin S, Molayo?lu HB, Baka M, Genin O, Pines M (2007). Effect of Temperature during the Incubation Period on Tibial Growth Plate Chondrocytes Differentiation and the Incidence of Tibial Dyschondroplasia.  Poult Sci. 86:1772-1783.

Genin O, Hasdai A, Shinder D, Pines M. (2008) Hypoxia, Hypoxia-Inducible Factor-1 Alpha (HIF-1a) and Heat-shock Proteins in Tibial Dyschondroplasia. Poult. Sci. 87(8):1556-1564.

Eggshell calcification

Lavelin I, Meiri N, Pines M. (2000). New insight in eggshell formation. Poult.Sci. 79:1014- 79:1014-1017.

Lavelin I, Meiri N, Genina O, Alexiev R, Pines M. (2001). Na-K-ATPase gene expression in the avian eggshell gland: distinct regulation in different cell types. Am. J. Physiol. Regul. Integr. Comp. Physiol. 281:R1169-R1176.

Lavelin I, Meiri N, Einat M, Genina O, Pines M. (2002).  Mechanical strain regulation of the Chicken glypican-4 gene expression in the avian eggshell gland. Am. J. Physiol.  283(4):R853-R861.

Fernandez MS, Escobar C, Lavelin I, Pines M, Arias JL. (2003)^. Localization of Osteopontin in Oviduct Tissue and Eggshell During Different Stages of the Egg Laying Cycle. J. Str. Biol. 143:171-180.

Arazi H, Yoselewitz I, Malka Y, Kelner Y, Genin O, Pines M. (2009). Osteopontin and Calbindin Gene Expression in the Eggshell Gland as Related to Eggshell Abnormalities. Poult Sci. 88(3):647-53.

Tissue fibrosis

Gnainsky Y, Spira G, Paizi M, Bruck R, Nagler A, Naffer Abu-Amar S, Geiger B, Genina O, Monsonego-Ornan E, Pines M. (2003). Halofuginone-an Inhibitor of Collagen Synthesis by Rat Stellate Cells-Stimulate Insulin-Like Growth Factor-Binding Protein 1 Synthesis by Hepatocytes. J. Hepatol.  40:269-277.

Pines M, Snyder D, Yarkoni S, Nagler A (2003).  Halofuginone to treat fibrosis in chronic graft versus host disease and scleroderma. Biol. Bl.  Marrow Transplant. 9:417-25

Bruck R, Schey R, Aeed H, Hochman A, Genina O, Pines M. (2004).  A protective effect of pyrrolidine dithiocarbamate in a rat model of liver cirrhosis. Liver Inter. 24:169-76.

Wengrower D, Zanninelli G, Pappo O, Lattela G, Sestieri M, Villanova A, Fatelson Y, Pines M, Goldin E. (2004). Prevention of fibrosis in experimental colitis by captopril: The role of TGFb1 Inflammatory Bowel Diseases. Inflamm. Bowel Dis. 10:536-545.

Yeikilis R, Gal S, Kopeiko N, Paizi M, Pines M, Braet F, Spira G. (2006). Hydrodynamics based transfection in normal and fibrotic rats. World J. Gastroenterol.  12: 6149-6155.

Gnainsky Y, Spira G, Paizi M, Bruck R, Nagler N, Genina G, Taub R, Halevy O, Pines M. (2006). The involvement of the tyrosine phosphatase early gene of liver regeneration (PRL-1) in cell cycle and in liver regeneration and fibrosis- effect of halofuginone. Cell Tissue Res. 324:385-394.

Haran N, Leschinski L, Pines M, Rapoport J. (2006). Inhibition of rat renal fibroblast proliferation by halofuginone. Nephron Exp Nephrol. 104:35-40.

Bruck R, Ashkenazi M, Weiss S, Shapiro H,  Aeed H, Genina O, Helpern Z, Pines       M, (2007). Prevention of liver fibrosis in rats by curcumin. Liver Int. 27:373-383.

Benchetrit S, Yarkoni S, Rathaus M, Pines M, Rashid G, Bernheim J, Bernheim     J.(2007). Halofuginone reduces the occurrence of renal fibrosis in 5/6 nephrectomized rats. Isr. Med. Assoc. J. 9:30-34.

Gnainsky Y, Kushnirsky Z, Bilu G, Hagai Y, Genina O, Volpin H, Bruck R, Spira G, Nagler A, Kawada N, Yoshizato K, Reinhardt DP, Libermann TA, Pines M. (2007). Gene expression during chemically induced liver fibrosis: effect of halofuginone on TGFb signaling. Cell Tissue Res. 328:153-166.

Huebner KD, Jassal DS, Halevy O, Pines M, Anderson JE. (2008) Functional resolution of fibrosis in mdx mouse dystrophic heart and skeletal muscle by halofuginone. Am J Physiol Heart Circ Physiol. 294(4):H1550-61

Pines M. (2008) Targeting TGFb signaling to inhibit fibroblasts activation as a therapy for fibrosis and cancer. Expt. Opinion Drug Dis. 3(1):11-20.

Ohayon O, Mawasi N, Pevzner A, Tryvitz A, Gildor T, Pines M, Rojkind M, Paizi M, Spira G. (2008) Halofuginone upregulates the expression of heparanase in thioacetamide-induced   liver fibrosis in rats.  Laboratory Invest. 88(6):627-633.

Turgeman T, Hagai Y, Huebner K_, Jassal DS, Anderson J, Genin O_, Nagler A, Halevy, O, Pines M. (2008) Inhibition of Smad3 phosphorylation by halofuginone prevents muscle fibrosis and improves muscle performance in the mdx mouse model of Duchenne muscular dystrophy, Neuromuscular Disorders. Neromuscul. Disorders 18(11):857-68.

Bruck R, Weiss S, Aeed H, Pines M, Halpern Z, Zvibel I. (2008). Additive Inhibitory Effect of Experimentally Induced Hepatic Cirrhosis by Agonists of Peroxisome Proliferator Activator Receptor gamma and Retinoic Acid Receptor. Dig Dis Sci. 54(2):292-9.

Zion O, Genin O, Kawada N, Yoshizato K, Roffe S, Nagler A, Iovanna JL, Halevy O, Pines M. (2009) Inhibition of TGFb Signaling by Halofuginone as a Modality for Pancreas Fibrosis Prevention. Pancreas 38(4):427-35.

Nevo Y, Halevy O, Genin O, Turgeman T, Harel M., Biton E, Reif S, Pines M. (2010).  Inhibition of fibrosis in laminin-a2-deficient congenital muscular dystrophy mice: effect of halofuginone. Muscle and Nerve In press.

Cancer-ECM interactions

Pinthus JH, Sheffer Y, Nagler A, Mor Y, Genina O, Pines M.  (2005). Inhibition of Wilm's tumor xenografts progression by halofuginone is accompanied by activation of WT1 gene expression. J. Urol.  174:1527-15231.

Yee KO, Caitlin M, Connolly BS, Pines M, Lawler J (2006). Halofuginone Inhibits Tumor Growth in the Polyoma Middle T Antigen Mouse via a Thrombospondin-1 Independent Mechanism. Cancer Biol. Ther. 5:218-224.

Taras D, Blanc JF, Rullier A, Dugot-Senant N, Laurendeau I, Vidaud M, Pines M, Rosenbaum J. (2006). Halofuginone suppresses lung metastasis of chemically-induced hepatocellular carcinoma in rats via MMP inhibition. Neoplasia 8(4):312-318.

Sheffer Y, Leon O, Pinthus JH, Nagler A, Mor Y, Genin O_, Iluz M_, Kawada N, Yoshizato K, Pines M (2007).  Inhibition of fibroblast to myofibroblast transition by halofuginone contribute to the chemotherapy-mediated anti-tumoral effect. Mol. Cancer Ther. 6:570-577.

Genin O, Rechavi G, Nagler A, Ben-Itzhak O, Nazemi K, Pines M. (2008) Myofibroblasts in pulmonary and brain metastases of alveolar soft-part sarcoma: a novel target for treatment? Neoplasia 10(9):940-8.

Spector I, Honig H, Kawada N, Nagler A, Genin O, Pines M. (2010).  Inhibition of Pancreatic Stellate Cells Activation by Halofuginone Prevents Pancreatic Xenograft Tumor Development.  Pancreas In press