Publications
Poultry bone disorders
Eswarakumar VP, Monsonego-Ornan E, Pines M, Antonopoulou I, Morriss-Kay GM, Lonai P. (2002). The IIIc alternative of Fgfr2 is a positive regulator of endochondral ossification. Development 129:3783-3793.
Tong A, Reich A., Genin O, Pines M, Monsonego-Ornan E. (2003).Expression of chicken 75-kDa gelatinase B-like enzyme in perivascular chondrocytes suggests its role in vascularization of the growth plate. J. Bone Miner. Res. 18:1443-452.
Pines M, Hasdai A and Monsonego-Ornan E. (2005). Tibial dyschondroplasia - tools, new insights and future prospects. World's Poult. Sci. J. 61:285-297.
Yalcin S, Molayo?lu HB, Baka M, Genin O, Pines M (2007). Effect of Temperature during the Incubation Period on Tibial Growth Plate Chondrocytes Differentiation and the Incidence of Tibial Dyschondroplasia. Poult Sci. 86:1772-1783.
Eggshell calcification
Lavelin I, Meiri N, Pines M. (2000). New insight in eggshell formation. Poult.Sci. 79:1014- 79:1014-1017.
Lavelin I, Meiri N, Genina O, Alexiev R, Pines M. (2001). Na-K-ATPase gene expression in the avian eggshell gland: distinct regulation in different cell types. Am. J. Physiol. Regul. Integr. Comp. Physiol. 281:R1169-R1176.
Lavelin I, Meiri N, Einat M, Genina O, Pines M. (2002). Mechanical strain regulation of the Chicken glypican-4 gene expression in the avian eggshell gland. Am. J. Physiol. 283(4):R853-R861.
Fernandez MS, Escobar C, Lavelin I, Pines M, Arias JL. (2003). Localization of Osteopontin in Oviduct Tissue and Eggshell During Different Stages of the Egg Laying Cycle. J. Str. Biol. 143:171-180.
Tissue fibrosis
Gnainsky Y, Spira G, Paizi M, Bruck R, Nagler A, Naffer Abu-Amar S, Geiger B, Genina O, Monsonego-Ornan E, Pines M. (2003). Halofuginone-an Inhibitor of Collagen Synthesis by Rat Stellate Cells-Stimulate Insulin-Like Growth Factor-Binding Protein 1 Synthesis by Hepatocytes. J. Hepatol. 40:269-277.
Pines M, Snyder D, Yarkoni S, Nagler A (2003). Halofuginone to treat fibrosis in chronic graft versus host disease and scleroderma. Biol. Bl. Marrow Transplant. 9:417-25
Bruck R, Schey R, Aeed H, Hochman A, Genina O, Pines M. (2004). A protective effect of pyrrolidine dithiocarbamate in a rat model of liver cirrhosis. Liver Inter. 24:169-76.
Wengrower D, Zanninelli G, Pappo O, Lattela G, Sestieri M, Villanova A, Fatelson Y, Pines M, Goldin E. (2004). Prevention of fibrosis in experimental colitis by captopril: The role of TGFb1 Inflammatory Bowel Diseases. Inflamm. Bowel Dis. 10:536-545.
Yeikilis R, Gal S, Kopeiko N, Paizi M, Pines M, Braet F, Spira G. (2006). Hydrodynamics based transfection in normal and fibrotic rats. World J. Gastroenterol. 12: 6149-6155.
Gnainsky Y, Spira G, Paizi M, Bruck R, Nagler N, Genina G, Taub R, Halevy O, Pines M. (2006). The involvement of the tyrosine phosphatase early gene of liver regeneration (PRL-1) in cell cycle and in liver regeneration and fibrosis- effect of halofuginone. Cell Tissue Res. 324:385-394.
Haran N, Leschinski L, Pines M, Rapoport J. (2006). Inhibition of rat renal fibroblast proliferation by halofuginone. Nephron Exp Nephrol. 104:35-40.
Bruck R, Ashkenazi M, Weiss S, Shapiro H, Aeed H, Genina O, Helpern Z, Pines M, (2007). Prevention of liver fibrosis in rats by curcumin. Liver Int. 27:373-383.
Benchetrit S, Yarkoni S, Rathaus M, Pines M, Rashid G, Bernheim J, Bernheim J.(2007). Halofuginone reduces the occurrence of renal fibrosis in 5/6 nephrectomized rats. Isr. Med. Assoc. J. 9:30-34.
Gnainsky Y, Kushnirsky Z, Bilu G, Hagai Y, Genina O, Volpin H, Bruck R, Spira G, Nagler A, Kawada N, Yoshizato K, Reinhardt DP, Libermann TA, Pines M. (2007). Gene expression during chemically induced liver fibrosis: effect of halofuginone on TGFb signaling. Cell Tissue Res. 328:153-166.
Huebner KD, Jassal DS, Halevy O, Pines M, Anderson JE. (2008) Functional resolution of fibrosis in mdx mouse dystrophic heart and skeletal muscle by halofuginone. Am J Physiol Heart Circ Physiol. 294(4):H1550-61
Pines M. (2008) Targeting TGFb signaling to inhibit fibroblasts activation as a therapy for fibrosis and cancer. Expt. Opinion Drug Dis. 3(1):11-20.
Cancer-ECM interactions
Pinthus JH, Sheffer Y, Nagler A, Mor Y, Genina O, Pines M. (2005). Inhibition of Wilm's tumor xenografts progression by halofuginone is accompanied by activation of WT1 gene expression. J. Urol. 174:1527-15231.
Yee KO, Caitlin M, Connolly BS, Pines M, Lawler J (2006). Halofuginone Inhibits Tumor Growth in the Polyoma Middle T Antigen Mouse via a Thrombospondin-1 Independent Mechanism. Cancer Biol. Ther. 5:218-224.
Taras D, Blanc JF, Rullier A, Dugot-Senant N, Laurendeau I, Vidaud M, Pines M, Rosenbaum J. (2006). Halofuginone suppresses lung metastasis of chemically-induced hepatocellular carcinoma in rats via MMP inhibition. Neoplasia 8(4):312-318.
Sheffer Y, Leon O, Pinthus JH, Nagler A, Mor Y, Genin O, Iluz M, Kawada N, Yoshizato K, Pines M (2007). Inhibition of fibroblast to myofibroblast transition by halofuginone contribute to the chemotherapy-mediated anti-tumoral effect. Mol. Cancer Ther. 6:570-577.