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STATE OF ISRAEL I MINISTRY OF AGRICULTURE AND RURAL DEVELOPMENT   
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About Institutes Public Relations Technology Transfer Students\International Information Center (Library) Administration
שלח באימייל הדפס
 
Name: Noam Meiri, Ph.D. (Researcher)
Units: Animal SciencePoultry and Aquaculture
Research Interests / Job description  
Tel:  +972-8-9484411 08-9484406
Cell: 050-6220411
Fax:+972-8-9475075
Email:    noam.meiri@mail.huji.ac.il
Office location:Rehovot - Faculty of Agriculture
Address:Institute of Animal Science
Agricultural Research Organization,
The Volcani Center,
P.O.Box 6, Bet Dagan 50250, Israel

Position: Head Institute of Animal Science

Research Interests / Job description
Identifying the molecular correlates underlying sensory development concentrating on thermal control establishment.

CV  

 

Epigenetics: mechanism of environmental influence on gene expression

 

Image title: Early life epigenetic regulation of CRH expression pattern in the PVN affects long-term stress response

Cramer, T, Rosenberg, T., Kisliouk T, Meiri N. (2019) Molecular Psychiatry 24, 935–935 (Image)

 CRH immunoreactive cells are abundant in the chicks’ PVN. (a), hematoxylin and eosin staining of the chicken brain section indicating the anatomical location of the PVN, lateral ventricle (LV), third ventricle (VIII) and the hippocampus (HP), at position A 7.6 (Kuenzel and Masson, 1998). (b), Immunofluorescent staining of frozen coronal brain sections of the hypothalamus area of 3-day-old chick, immunostained with anti-CRH antibody and DAPI. (c), Magnification of the hypothalamic PVN are showing the abundance of CRH immunoreactive cells. 

 

Selected References 

 

Rosenblum, K., Meiri, N. and Dudai, Y. (1993). Taste memory: the role of protein synthesis in gustatory cortex. Behavioral and Neural Biology 59, 49-56.  (Re-named - Neurobiology of learning and memory

 

Meiri, N., Masos, T., Rosenblum, K., Miskin, R. and Dudai Y. (1994). Overexpression of urokinase-type plasminogen activator in transgenic mice is correlated with impaired learning. Proc. Natl. Acad. Sci. USA, 91:3196-3200. 

 

Rosenblum, K., Schul, R., Meiri, N., Hadari, Y., Zick, Y. and Dudai Y. (1995). Modulation of protein tyrosine phosphorylation in rat insular cortex following conditioned taste aversion. Proc. Natl. Acad. Sci. USA, 92:1157-1162. 

 

Meiri, N., Ghelardini, C., Tesco, G., Galeotti, N., Dahl, D., Tomsic, D., Cavallaro, S., Quattrone, A., Capaccioli, S., Bartolini, A. and Alkon D. L. (1997). Reversible Antisense inhibition of Shaker-like kv1.1 potassium channel expression impairs associative memory in mouse and rat. Proc. Natl. Acad. Sci. USA, 94:4430-4434. 

 

Cavallaro, S., Meiri, N., Chu-Li, Y., Musco, S., Ma, W., Goldberg, J. and Alkon D. L. (1997). Late memory-related genes in the hippocampus revealed by RNA fingerprinting. Proc. Natl. Acad. Sci. USA, 94:9669-9673. 

 

Meiri, N. and Rosenblum, K. (1998). Lateral ventricle injection of the protein synthesis inhibitor anisomycin impairs long-term memory in a spatial memory task.  Brain Res. 789/1: 48-55. 

 

Okaba, S., Collin, C., Auerbach, J. M., Meiri, N., Bengazon, J., Kennedy, M. B., Segal, M. and McKay, R. D. (1998). Hippocampal synaptic plasticity in mice overexpressing an embryonic subunit of the NMDA recepto`r. J. Neuroscience 18:4177-4188. 

 

Meiri, N., Sun, M. K-., Segal, Z. Alkon D.L. (1998) Memory and LTP dissociated:  normal spatial memory despite CA1 LTP elimination with Kv1.4 antisense. Proc. Natl. Acad. Sci. USA  95: 15037-15042.  

 

Lamensdorf, I., Meiri, N., Harvey-White, J. D., Jacobowitz, M. J. and Kopin I. J. (1999) Oligoantisense for Kir6.2 diminished contralateral turning induced by apomorphine in the 6-hydroxydopamine hemiparkinsonian rat model. Brain Res. 818/2: 275-284. 

 

Zhao, W., Chen, H., Xu H., Moore E., Meiri N., Quon M.J. and Alkon D.L. (1999) Brain insulin receptors and spatial memory: correlated changes in gene expression, tyrosine phosphorylation, and signaling molecules. J. Biol. Chem. 274:34893-34902.  

 

Zhao W., Meiri N., Xu H., Cavallaro, S., Quatrone A., Zhang, L. and Alkon, D.L. (2000) Spatial learning induced changes in expression of the ryanodine type II receptor in the rat hippocampus. FASEB J. 14:290-300

 

Lavelin, I., Meiri N. and Pines, M. (2000) New insight in eggshell formation Poultry Science 79:1014-1017. 

 

Mor, I, Grisaru, D., Evron, T., Richler, C., Wahrman, J., Sternfeld, M., Yogev, L., Titelbaum, L., Meiri, N., Seidman, S. and Soreq, H. (2001) Modified testicular expression of stress-associated “readthrough” acetylcholinesterase predicts male infertility. FASEB J. 15:2039-41. 

 

Lavelin, I., Meiri, N., Genina, O., Alexiev, R. and Pines, M. (2001) Alfa-1 subunit of Na-K-ATPase gene expression in the avian eggshell gland: distinct mechanisms of regulation in different cell types. Am J Physiol Regul Integr Comp Physiol. 281:R1169-R1176. 

 

Lavelin, I., Meiri, N., Einat, M., Genina, O. and Pines, M. (2002) Mechanical strain regulation of the chicken glypican-4 gene expression in the avian eggshell gland. Am J Physiol Regul Integr Comp Physiol 283:R853-61. 

 

Edelheit, S. and Meiri, N. (2004) Cyclin S: A new member of the cyclin family plays a role in long-term memory Eur. J. Neurosci. 19:365-75. 

 

Labunskay, G. and Meiri, N., (2006) R-Ras3/(M-Ras) is involved in thermal adaptation in the critical period of thermal control establishment. J. Neurobiol. 66:56-70. (re-named Developmental Neurobiology) 

 

Katz, A. and Meiri, N., (2006) Brain-Derived Neurotrophic Factor (BDNF) is Critically Involved in Thermal-Experience-Dependent Developmental Plasticity. J. Neurosci. 26:3899-3907. 

 

Yefet, K., Merhav, M., Cuulman-Vander, S., Elkobi, A., Belelovsky, K., Jacobson-Pick, S., Meiri, N. and Rosenblum K. (2006) Different Signal Transduction Cascades are Activated Simultaneously in the Cortex and Hippocampus Following Novel Taste Learning. Eur J Neurosci. 24:1434-1442. 

 

Tirosh, S., Elkobi, A. Rosenblum, K. and Meiri, N. (2007) A Role for Eukaryotic Translation Initiation Factor 2B (eIF2B) in Taste Memory Consolidation. Developmental Neurobiology 67:728-739.

 

Meiri, N. (2008) 14-3-3ε expression is induced during the critical period of thermal control establishment. Developmental Neurobiology 68:62-72.

 

Yossifoff, M., Kisliouk, T. and Meiri, N. (2008) Dynamic changes in DNA methylation during thermal control establishment affect CREB binding to the Brain-derived neurotrophic factor promoter. Eur. J. Neurosci. 28:2267-2277. IF. 3.75, Category: Neuroscience; Rank 85/251; 62  

 

Kisliouk, T and Meiri, N.  (2009) A critical role for dynamic changes in histone H3 methylation at the Bdnf promoter during postnatal thermotolerance acquisition. Eur. J. Neurosci 30:1909-1922

 

Kisliouk, T., Ziv, M, and Meiri, N. (2009) Epigenetic control of translational regulation: Alterations in histone H3 lysine 9 post-translational modifications are correlated with expression of the translation initiation factor 2B (Eif2b5) during thermal-control establishment Developmental Neurobiology 70:100-113. 

 

Kisliouk T., Yosefi, S. and Meiri N. (2011) MiR-138 inhibits EZH2 methyltransferase expression, methylation of histone H3 at Lysine 27 and affects thermotolerance acquisition. Eur. J. Neurosci 33:224-235. 

 

Xu, P., Denbow, C. J., Meiri N., and Denbow, DM. (2012) Fasting of 3-day-old chicks leads to changes in histone H3 methylation status. Physiol and Behav. 105:276-82.   

 

Kisliouk, T and Meiri, N. (2013) MiR-138 promotes migration of cultured chicken embryonic hypothalamic cells by targeting reelin. Neuroscience 238:114-124. 

 

Marco, A., Kisliouk, T., Weller, A. and Meiri, N. (2013) High fat diet induces hypermethylation of the hypothalamic Pomc promoter and obesity in post-weaning rats. Psychoneuroendocrinology 38:2844-2853

 

Marco, A., Kisliouk, T., Tabechnik, T., Meiri, N and Weller, A. (2014) Overweight and CpG methylation of the Pomc promoter in offspring of high-fat-diet-fed dams are not “reprogrammed” by regular chow diet in rats FASEB J. 

 

Kisliouk, T Cramer, T. and Meiri, N. (2014) heat stress attenuates new cell generation in the hypothalamus: a role for mir-138. Neuroscience 277: 624-636 

 

Cramer, T., Kisliouk, T., Yeshurun, S., and Meiri N. (2015) The balance between stress resilience and vulnerability is regulated by corticotropin-releasing hormone during the critical postnatal period for sensory development. Developmental Neurobiology 75(8):842-53. 

 

Jiang Y., Denbow, C. Jc., Meiri Nc., and Denbow, DM. (2016) Epigenetic-imprinting changes caused by neonatal fasting stress protect from future fasting stress J. Neuroendocrinology 28(1). doi: 10.1111/jne.12333. 

 

Marco, A., Kisliouk, T., Tabachnik, T., Weller, A. and Meiri, M. (2016) DNA CpG methylation (5mC) and its modification (5hmC) alter histone post-translational modifications at the Pomc promoter, affecting the impact of perinatal diet on leanness and obesity of the offspring. Diabetes, 65(8):2258-67.

 

Tabachnik, T., Kisliouk, T., Marco, A., Meiri, N., Weller A. (2017) Thyroid hormone-dependent epigenetic regulation of melanocortin 4 receptor levels in female offspring of obese rats. Endocrinology 158(4):842-851. 

 

Kisliouk T, Cramer T, Meiri N. (2017) Methyl CpG level at distal part of heat-shock protein promoter HSP70 exhibits epigenetic memory for heat stress by modulating recruitment of POU2F1-associated nucleosome-remodeling deacetylase (NuRD) complex. J Neurochem. 141(3):358-372.

 

Cramer, T, Rosenberg, T., Kisliouk T, Meiri N. (2019) Early-life epigenetic changes along the corticotropin-releasing hormone (CRH) gene influence resilience or vulnerability to heat stress later in life. Molecular Psychiatry 24:1013-1026. 

 

         Cramer, Ts, Rosenberg, Ts., Kisliouk T, Meiri N. (2019) Early life epigenetic regulation of CRH expression pattern in the PVN affects long-term stress response Molecular Psychiatry 24, 935–935 (Image)

 

Cramer, T, Rosenberg, T., Kisliouk T, Meiri N. (2019) PARP inhibitor affects long-term heat-stress response via changes in DNA methylation. Neuroscience 399:65-76. 

 

Kisliouk, T., Rosenberg T, Ben-Nun O, Ruzal M. and Meiri N. (2020) Early-life m6A RNA demethylation by fat mass and obesity-associated protein (FTO) influences resilience or vulnerability to heat stress later in life. eNeuro (In Press). 

 

 

 

 


 

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