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שלח באימייל הדפס
Name: Noam Meiri, Ph.D. (Researcher)
Units: Animal SciencePoultry and Aquaculture
Research Interests / Job description  
Tel:  +972-8-9484411 08-9484406
Cell: 050-6220411
Email:    noam.meiri@mail.huji.ac.il
Office location:Rehovot - Faculty of Agriculture
Address:Department of Poultry Science
Institute of Animal Science
Agricultural Research Organization,
The Volcani Center,
P.O.Box 6, Bet Dagan 50250, Israel
Research Interests / Job description
Identifying the molecular correlates underlying sensory development concentrating on thermal control establishment.

 BARD workshop

Affecting early life poultry development to improve domestic fowl livestock 

Epigenetics: mechanism of environmental influence on gene expression

Expression pattern of the H3K27-specific methyltransferase, EZH2, in the PO/AH of 3-day-old chicks


 Colocalization of EZH2 and H3K27me2 in PO/AH cells by double immunohistochemical staining. Representative pictures of the same field of the PO/AH of 12-h heat-treated chicks. The brain section was photographed at 200X magnification under different filters, enabling the visualization of fluorescent signals from FITC (upper left panel), Cy3 (upper right panel) and DAPI (lower right panel). The merging of H3K27me2 and EZH2 pictures (lower left panel)

Selected References 


Meiri, N., Masos, T., Rosenblum, K., Miskin, R. and Dudai Y. (1994). Overexpression of urokinase-type plasminogen activator in transgenic mice is correlated with impaired learning. Proc. Natl. Acad. Sci. USA, 91:3196-3200.


Meiri, N., Ghelardini, C., Tesco, G., Galeotti, N., Dahl, D., Tomsic, D., Cavallaro, S., Quattrone, A., Capaccioli, S., Bartolini, A. and Alkon D. L. (1997). Reversible Antisense inhibition of Shaker-like kv1.1 potassium channel expression impairs associative memory in mouse and rat. Proc. Natl. Acad. Sci. USA, 94:4430-4434.


Cavallaro, S., Meiri, N., Chu-Li, Y., Musco, S., Ma, W., Goldberg, J. and Alkon D. L. (1997). Late memory-related genes in the hippocampus revealed by RNA fingerprinting.  Proc. Natl. Acad. Sci. USA, 94:9669-9673.


Meiri, N. and Rosenblum, K. (1998). Inhibition of protein synthesis in the rat brain impairs long-term   memory in a spatial memory task  Brain Res. 789/1: 48-55.


Meiri, N., Sun, M. K-., Segal, Z. Alkon D.L. (1998) Memory and LTP dissociated:  normal spatial memory despite CA1 LTP elimination with Kv1.4 antisense. Proc. Natl. Acad. Sci. USA  95: 15037-15042. 


Zhao W., Meiri N., Xu H., Cavallaro, S., Quatrone A., Zhang, L. and Alkon, D.L. (2000) Spatial learning induced changes in expression of the ryanodine type II receptor in the rat hippocampus. FASEB J. 14(2):290-300.


Edelheit, S. and Meiri, N. (2004) Cyclin S : A new member of the cyclin family plays a role in long-term memory Eur. J. Neurosci. 19(2):365-75.


Labunskay, G. and  Meiri, N., (2006) R-Ras3/(M-Ras) is involved in thermal adaptation in the critical period of thermal control establishment. J. Neurobiol. 66:56-70.


Katz, A. and  Meiri, N., (2006) Brain-Derived Neurotrophic Factor (BDNF) is Critically Involved in Thermal-Experience-Dependent Developmental Plasticity. J. Neurosci. 26:3899-3907.


Tirosh, S., Elkobi, A., Rosenblum, K. and  Meiri, N. (2007)  A Role for Eukaryotic Translation Initiation Factor 2B (eIF2B) in Taste Memory Consolidation. Developmental Neurobiology 67:728-739.


Meiri, N. (2008) 14-3-3ε expression is induced during the critical period of thermal control establishment. Developmental Neurobiology 68:62-72.


Yossifoff, M., Kisliouk, T. and Meiri, N. (2008) Dynamic changes in DNA methylation during thermal control establishment affect CREB binding to the brain-derived neurotrophic factor promoter. Eur J Neurosci. 28:2267-2277.


Kisliouk T, and Meiri N. (2009) A critical role for dynamic changes in histone H3 methylation at the Bdnf promoter during postnatal thermotolerance acquisition. Eur J Neurosci. 30:1909-1922.



 Kisliouk, TS Ziv, MS, and Meiri, N. (2009) Epigenetic control of translational regulation: Alterations in histone H3 lysine 9 post-translational modifications are correlated with expression of the translation initiation factor 2B (Eif2b5) during thermal-control establishment Developmental Neurobiology 70:100-113. 


Kisliouk TS., Yosefi, S. and Meiri N. (2011) MiR-138 inhibits EZH2 methyltransferase expression, methylation of histone H3 at Lysine 27 and affects thermotolerance acquisition. Eur. J. Neurosci 33:224-235. 


Xu, P., Denbow, C. J., Meiri N., and Denbow, DM. (2012) Fasting of 3-day-old chicks leads to changes in histone H3 methylation status. Physiol and Behav. 105:276-82.  


Kisliouk, T and Meiri, N.  (2013) MiR-138 promotes migration of cultured chicken embryonic hypothalamic cells by targeting reelin. Neuroscience 238:114-124. 


Marco, A., Kisliouk, T., Weller, A. and Meiri, N. (2013) High fat diet induces hypermethylation of the hypothalamic Pomc promoter and obesity in post-weaning rats. Psychoneuroendocrinology 38:2844-2853. 


Marco, A., Kisliouk, Ts., Tabechnik, Ts., Meiri, N and Weller, A. (2014) Overweight and CpG methylation of the Pomc promoter in offspring of high-fat-diet-fed dams are not “reprogrammed” by regular chow diet in rats FASEB  J. (fj.14-255620. Published online July 23, 2014)


Kisliouk, T Cramer T. and Meiri, N. (2014) heat stress attenuates new cell generation in the hypothalamus: a role for mir-138. Neuroscience 277: 624-636


Cramer, T., Kisliouk, T., Yeshurun, S., and Meiri N. (2015) The balance between stress resilience and vulnerability is regulated  by corticotropin-releasing hormone during the critical postnatal  period for sensory development. Developmental Neurobiology 75:842-853  


Jiang Y., Denbow, C. J., Meiri N., and Denbow, DM. (2016) Epigenetic-Imprinting Changes Caused by Neonatal Fasting  Stress Protect From Future Fasting Stress J.  Neuroendocrinology 28(1). doi: 10.1111/jne.12333


Marco, A., Kisliouk, T., Tabachnik, T., Weller, A. and Meiri, M. (2016) DNA CpG methylation (5mC) and its modification (5hmC) alte histone post-translational modifications at the Pomc promoter, affecting the impact of perinatal diet on leanness and obesity of the offspring. Diabetes, 65(8):2258-67.


Tabachnik, T., Kisliouk, T., Marco, A., Meiri, N., Weller A. (2017) Thyroid hormone-dependent epigenetic regulation of  melanocortin 4 receptor levels in female offspring of obese rats. Endocrinology 158(4):842-851.







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