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About Institutes Public Relations Technology Transfer Students\International Library Administration
שלח באימייל הדפס
Name: Sigal Brown Miyara, Ph.D. (Researcher)
Units: Plant ProtectionEntomology and the Nematology and Chemistry units
Research Interests / Job description  
Tel:  972-3-9683353
Cell: 972-50-6220084
Email:    sigalhor@volcani.agri.gov.il
Office location:Nematology Unit, Plant Protection Institute
Address:Dept. of Entomology and the Nematology and Chemistry units, ARO, The Volcani Center
Derech Hamacabim 68, Bet Dagan 50250


Research Interests / Job description
A. Studying the role of lipid signals in regulating plant response to plant parasitic nematodes.

B. Studying the occurrence of Root Knot Nematode breaking resistance populations on tomato and pepper plants carrying resistance genes.

C. Developing new friendly biological control agents toward reducing the damage caused by plant parasitic nematodes.




Freeman, S., Horowitz, S. and Sharon, A. (2001).Pathogenic and Nonpathogenic lifestyles in Colletotrichum acutatum from strawberry and other plants. Phytopathology 91:986-992.

Horowitz, S., Freeman, S. and Sharon, A. (2002). Use of GFP transgenic strains to study pathogenic and non-pathogenic lifestyles in Colletotrichum. Phytopathology 92:743-749.

Horowitz, S., Yarden, O., Zveibil, A. and Freeman, S. (2004).Development of a robust screeningmethod for pathogenicity of Colletotrichum spp. on strawberry seedlings enabling forward genetic studies. Plant Dis. 88:845-851.

Horowitz, S., Freeman, S., Zveibil, A. and Yarden, O. (2006). A defect in nir1, a nirA-like transcription factor, confers morphological abnormalities and loss of pathogenicity in Colletotrichum acutatum. Mol. Plant. Pathol. 7:341-354.

Horowitz Brown, S., Yarden, O., Gollop, N., Chen, S., Zveibil, A., Belausov, E. Freeman, S (2008). Differential protein expression in Colletotrichum acutatum: changes associated with reactive oxygen species (ROS) and nitrogen starvation implicated in  pathogenicity on strawberry. Mol. Plant. Pathol. 9:171-190.

Horowitz Brown, S., Zarnowski, R., Sharpee, W.C. and Keller, N. P. (2008). Morphological transitions governed   by density dependence and lipoxygenase activity in Aspergillus flavus. Appl. Environ. Microb.  74: 5674-5685.

Horowitz Brown, S., Scott, B. J., Bhaheetharan, J.,  Sharpee, W. C., Milde, L.  and Keller, N. P. (2009). Oxygenases coordination is required for morphological transition and the host/fungal interaction of Aspergillus flavus. MPMI. 22:882-894. 

Georgianna, D.R., Fedorova, N.D., Burroughs, J.L., Dolezal, A.L., Bok, J.W., Horowitz Brown, S., Woloshuk, C., Yu, J., Keller, N.P. and Payne, G.A. (2009). Beyond aflatoxin: four distinct expression patterns and functional roles associated with Aspergillus flavus secondary metabolism gene clusters. Mol. Plant  Pathol. 11:   213-226.

Gao, X., Brodhagen, M., Isakeit, T., Horowitz Brown, S., Göbel, C., Betran, J., Feussner, I., Keller, N. P. And Kolomiets, M. V. (2009). Inactivation of the lipoxygenase ZmLOX3 increases susceptibility of maize to Aspergillus spp. MPMI. 22(2):222-31.

Barad, S*., Brown Horowitz, S*., Moskovitch, O., Lichter, A., Sherman, A. and Prusky, D. (2012). Penicillium expansum Glucose Oxidase-Encoding Gene, GOX2, Is Essential for Gluconic Acid Production and Acidification During Colonization of Deciduous Fruit. MPMI. 25:779-88.

Iberkleid, IS., Vieira, P., de Almeida Engler, J., Spiegel, Y. and Brown Horowitz, S. (2013(.Mj-FAR-1, a Fatty Acid-and Retinol-Binding protein secreted by Root-Knot Nematodes is required for tomato host susceptibility to Meloidogyne javanica. PLoS ONE 8(5): e64586. doi:10.1371/journal.pone.0064586.


Iberkleid, IS., Ozalvo, RT., Feldman, L., Elbaz, M., Bucki, P. and Brown Horowitz Sigal. (2014). Studying the responses of tomato genotypes to Mi- avirulent and virulent Meloidogyne javanica isolates occurred in Israel. Phytopathology 104(5):484-496.


 Barad, S., Brown Horowitz, S., Kobiler, I., Sherman, A., and Prusky, D. (2014). Accumulation of the mycotoxin patulin in the presence of gluconic acid  contributes to pathogenicity of Penicillium expansum. MPMI. 27:66-77.

Ozalvo, RT., Cabrera, J., Escobar, C., Castresana, C., Shawn, A. C., Kolomiets, M. V., Iberkleid, I. and Brown Horowitz, S. (2014). Two closely member of Arabidopsis 13-LOXs, LOX3 and LOX4 reveals distinct function in response to plant parasitic nematode infection. Mol. Plant  Pathol. 15(4):319-32. 


Iberkleid, I., Sela, N., and Horowitz Brown, S. (2015). Meloidogyne javanica fatty acid- and retinol-binding protein (Mj-FAR-1) regulates expression of lipid-, cell wall-, stress- and phenylpropanoid-related genes during nematode infection of tomato. BMC Genomics. 16:272.

Iberkleid, I., Yeheskel, A., Belausov, E. and Horowitz Brown, S. (2015). Structural Characterization and Localization Analysis of the Root-Knot Nematode Meloidogyne javanica Fatty Acid and Retinol Binding Protein  (Mj-FAR-1). EJPP. 143:133–149.


Book Chapters

Horowitz S., Zveibil, A., Sharon, A., Yarden, O., and Freeman, S. (2005) Epiphytic and endophytic interactions in Colletotrichum species. In: Emerging Trends in Plant-Microbe Interactions. Eds. S.S. Gnanamanickam, R. Balasubramanian and N. Anand, pp 94-102 Chennai, India, Dec. 8-10, 2005.

Prusky, D., Alkan, N., Miyara, I., Barad, S., Davidzon, M., Kobiler, Brown Horowitz, S., Lichter, A.., Sherman, A. and Fluhr, R. (2009). Mechanisms Modulating Postharvest Pathogen Colonization of Decaying Fruits. In: Post Harvest Pathology. eds. Prusky, D. and Gullino, M.L. pp. 43-55. Springer Netherlands.


Escobar, C., Brown-Horowitz S. and Goellner-Mitchum, M., (2011). Transcriptomic and proteomic analysis of the plant response to nematode infection. In: Genomics and Molecular Genetics of Plant-Nematode Interactions. Jones, J., Fenoll, C. and  Gheysen,  L. (Eds). pp. 157-174. Springer Dordrecht Heidelberg London New York.


Brown Miyara, S., Ionit, I., Buki, P., & Kolomiets, M. (2015). The Role of Lipid Signalling in Regulating Plant Nematode Interactions. In Plant Nematode Interactions: A View on Compatible Interrelationships. C. Escobar, & C. Fenoll (Eds.) pp. 139–166  Advances in Botanical Research, Volume 7 http://dx.doi.org/10.1016/bs.abr.2014.12.004




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