כיווני המחקר
פיתוח אמצעים ביוטכנולוגיים ותזונתיים להשפעה על התיאבון, צבירת שומן וביצועי מערכת הרבייה.
שימוש בשיטה ייחודית למדידת פעילות לפטין בדוגמאות ביולוגיות, המבוססת על ביטוי של הקולטן ללפטין של אדם ושל עופות בתאים בתרבית.
שימוש בשיטות פרוטאומיות לאנליזה של חלבונים מופרשים מרקמת השומן ולהבנת התפקיד האנדוקריני של רקמת השומן בעופות.
פיתוח שיטות להחדרת גנים לעופות כדי לאתר גנים שתוצריהם משפיעים על מדדי הייצור.
List of Publications
Friedman, M., Revel, M. and Kimchi, A. (1981). Initial characterization of a spontaneous interferon secreted during growth and differentiation of Friend erythroleukemia cells. Mol. Cel. Biol. 2: 1472-1480.
Revel, M., Kimchi, A., Friedman, M., Wolf, D., Merlin, G., Panet, A., Rapoport, Y. and Lapidot, Y.(1982). Cell-regulatory function of interferon induced enzymes: antitumorogenic effect of (2'-5') oligo-A, growth relate variations in (2'-5') oligo-A synthetase, and isolation of its mRNA. Texas Reports on Biology and Medicine, 41: 452-462.
Einat, M., Resnitzky, D. and Kimchi, A. (1985).Close link between reduction of c-myc expression by interferon and Go/G1 arrest. Nature 313: 597-600.
Einat, M., Resnitzky, D. and Kimchi, A. (1985). Inhibitory effects of interferon on the expression of genes regulated by platelet-derived growth factor.Proc. Natl. Acad. Sci. USA 82: 7608-7612.
Einat, M. and Kimchi, A. (1988). Transfection of fibroblasts with activated c-myc confers growth resistance to antigrowth affect of interferon. Oncogene. 2: 485-491.
Shashikant C.S., Utset M.F., Violette S.M., Wise T.L., Einat P., Friedman-Einat M.,Pendleton J., Schughart K. and Ruddle F.H. (1991). Homeobox genes in mouse development. CRC Critical Reviews in Eukaryotic Gene Expression 1; 207-245.
Fainstein, E., Einat, M., Gokkel, E., Marcelle, C., Croce, C.M., Gale, R.P. and Canaani, E. (1989).Nucleotide sequence analysis of human abl and bcr-abl cDNAs. Oncogene. 4; 1477-1481.
Friedman-Einat, M., Einat, P., Snyder, M. and Ruddle, F. (1996). Target gene identification: target specific transcriptional activation by three murine homeodmain/VP16 hybrid proteins in Saccharomyces Cerevisiae. J. Exp. Zool. 274; 145-156.
Friedman-Einat, M., Haberfeld, A., Shamay, A., Horev, G., Hurwitz, S. and Yahav, S. (1996). A novel 29-kDa chicken heat shock protein. Poult. Sci. 75: 1528-1530.
Yahav, S., Shamay, A., Rossel, M., Horev, G., Hurwitz, S., Dotan, M. and Friedman-Einat, M. (1996). Induction of thermotolerance; physiological and molecular aspects. Meshek Ha'ofot (in Hebrew) November-December: 25-33.
Friedman-Einat, M., Grossmann, Z., Mileguir, F., Smetana, Z., Ashkenazi, M., Barkai, G., Varsano, N., Glick, E. and Mendelson, E. (1997). Detection of adeno associated virus type 2 (AAV2) sequences in the human genital tract. J. Clin. Microbiol. 35: 71-78.
Yahav, S., Shamay, A., Horev, G., Bar-Ilan, D., Genina, O. and Friedman-Einat, M. (1997). Effect of acquisition of improved thermotolerance on the induction of heat-shock proteins in broiler chickens. Poult. Sci. 76: 1428-1434.
Diaz, R., Hurwitz, S., Chatopadhyay, N., Pines, M., Yang, Y.H., Kifor, O., Friedman-Einat, M., Butters, R., Hebert, S.C. and Brown E.M. (1997). Cloning, expression, and tissue localization of the calcium-sensing receptor in chicken (Gallus domesticus). Am. J. Physiol. 273: R1008-R1016.
Friedman-Einat, M., Boswell, T., Horev, G., Girishvarma, G., Dunn,I.C., Talbot, R.T. and Sharp P.J. (1999). The Chicken Leptin Gene: Has it Been Cloned? J. Comp. Gen. Endo. 115: 354-363.
Horev, G., Einat, P., Aharoni, T., Eshdat, Y. and Friedman-Einat, M. (2000). Molecular Cloning and Properties of the Chicken Leptin-Receptor (CLEPR) gene. Mol. Cell. Endo 162: 95-106.
Dunn, I. C., Boswell, T., Friedman-Einat, M., Eshdat, Y., Burt, D. and Paton, I.R. (2000). Mapping of the chicken leptin receptor gene (CLEPR) to chicken chromosome 8. Anim. Genet., 31: 290.
Lavelin I., Meiri N., Einat M., Genina O. and Pines M. (2002). Chicken glypican-4 gene expression: Regulation by mechanical strain and involvement in eggshell formation Am J Physiol Regul Integr Comp Physiol. 283: R853-R861.
Friedman-Einat, M., Kaluta, V. and Rosal, M. (2002). The genetic control on obesity in poultry. Meshek Ha'ofot (in Hebrew, reviewed) May-Jun: 23-26.
Marikovsky, M., Rosenblum, C., Faltin, Z. and Friedman-Einat, M. (2002). Appearance of leptin in wound fluid as a response to injury. Wound Rep.Reg. 10: 302-307.
Friedman-Einat, M., Camoin, L., Faltin, Z., Rosenblum, C.I., Kaliouta, V., Eshdat, Y. and Strosberg, A.D. (2002). Serum leptin activity in obese and lean Patients. Reg. Pept. 111: 77 - 82.
Friedman-Einat, M., Plavnick, Y,. Rosal, M. Yahav, S. and Malca, Y. (2003). Comparative study of commercial layer strains - first period of study number 13.Meshek Ha'ofot (in Hebrew) Spt, 22-25.
Freidman-Einat M, and Zaffriri Dina, (2004). Why are we getting fat? A book in a series of popular science. Ed. Zvi Atzmon. Publisher MAPA
Niv-Spector L, Raver N, Friedman-Einat M, Grosclaude J, Gussakowsky EE, Livnah O, Gertler A. (2005). Mapping leptin-interacting sites in recombinant leptin-binding domain (LBD) subcloned from chicken leptin receptor. Biochem J. 391:221-230.
Hen, G.. Bor, A. Simchaev, V. Druyan, S. Yahav, S. Miao, CH, and Friedman-Einat, M. (2006). Expression of foreign genes in chicks by hydrodynamics-based naked plasmid transfer in vivo. Domestic Animal Endocrinology. 30: 135-143.
Chen K, Li F, Li J, Cai H, Strom S, Bisello A, Kelley DE, Friedman-Einat M, Skibinski GA, McCrory MA, Szalai AJ, Zhao AZ (2006). Induction of Leptin Resistance through Direct Interaction of C-Reactive Protein with Leptin. Nature Medicine, 12(4):425-432.
Hen, G., Yosefi, S., Simchaev, V., Shinder, D., Hruby, V.J., and Friedman-Einat, M. (2006). The melanocortin circuit in obese and lean strains of chicks. J Endocrinol 190(2): 527-535.
Bohlen, F., Kratzsch, J., Mueller, M., Seidel, B., Friedman-Einat, M., Witzigmann, H., Teupser, D., Koerner, A., Storck, M., and Thiery, J. (2007). Leptin inhibits cell growth of human vascular smooth muscle cells. Vascul Pharmacol 46(1): 67-71.
Hen, G., Yosefi, S., Ronin, A., Einat, P., Rosenblum, C.I., Denver, R.J., and Friedman-Einat, M. (2008). Monitoring leptin activity using the chicken leptin receptor. J Endocrinol 197(2): 325-333
Faltin, Z., Holland, D., Velcheva, M., Tsapovetsky, M., Roeckel-Drevet, P., Handa, A.K., Abu-Abied, M., Friedman-Einat, M., Eshdat, Y., and Perl, A. (2010). Glutathione peroxidase regulation of reactive oxygen species level is crucial for in vitro plant differentiation. Plant Cell Physiol 51(7): 1151-1162.
Yosefi, S., Hen, G., Rosenblum, C., Cerasale, D.J., Beaulieu, M., Criscuolo, F., and Friedman-Einat, M. (2010). Lack of leptin activity in blood samples of Adelie penguin and Bar-tailed godwit. (2010) J Endocrinol.. 207(1):113-122.
This paper was reviewed in "Endocrine news", November 2010.
Novoslovsky, N., Nussinovitch, A., and Friedman-Einat, M. (2010). Attenuation of food intake in chicks by an inverse agonist of cannabinoid receptor 1 administered by either injection or ingestion in hydrocolloid carriers. Gen. & Comp. Endocrinol. In press.
Patents
Friedman-Einat, M., Horev, G. and Eshdat Y. (1999). Polynucleotide's and polypeptides of avian leptin receptor. US patent IL00/00674.