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STATE OF ISRAEL I MINISTRY OF AGRICULTURE AND RURAL DEVELOPMENT   
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About Institutes Public Relations Technology Transfer Students\International Library Administration
שלח באימייל הדפס
 
Name: Vinnie (Miriam) Altstein, Prof. (Researcher)
Units: Plant ProtectionEntomology and the Nematology and Chemistry units
Research Interests / Job description  
Tel:  03-9683710
Cell: 050-6220709
Fax:03-9683835
Email:    vinnie2@agri.gov.il
Office location:The Volcani Center, Bet Dagan
Address:Department of Entomology
Agricultural Research Organization
The Volcani Center
P.O.Box 6, Bet Dagan 50250, Israel
Research Interests / Job description
General:
1. Neuroendocrinology and neurochemistry
2. Rational design of insecticides
3. Molecular diagnostics
4. Food toxicology

Specific topics:
1. Studies of neuroendocrine mechanisms in moths (sex pheromone biosynthesis, melanization, pupariation, muscle contraction, diapause).
2. Rational design of environment friendly non-toxic insect control agents based on disruption of the neuroendocrine system (i.e., design of neuropeptide-antagonist based insecticides).
3. Studies of bioavailability (penetrability through the cuticle) of compounds into insects.
4. Development of receptor based high throughput screening assays for discovery of new insect control agents.
5. Development of novel probes and immunochemical/microarray methods for monitoring pesticide residues from water, food and environmental samples.

Education, training and teaching

1969 - 1972:         B.Sc. Biology, Tel Aviv University, Israel.
1972 - 1974:         M.Sc. Virology, Tel Aviv University, Israel.
1979 - 1984:         Ph.D. Neurobiology, Weizmann Institute of Science, Israel.
1984 - 1987:         Post doc, Neurochemistry, NIH, Bethesda, MD, USA.
1987 - current:      Full Professor, Volcani Center, ARO, Israel.
2000 - 2002:         Sabbatical, Cell Biology and Neurosciences, UCR, 
                             Riverside CA, USA.
2007 - 2010          Guest lecturer: "Food Toxicology", Hebrew University of 
                             Jerusalem, Faculty of Agriculture, Rehovot, Israel.

List of Publications

PEER REVIEWED ARTICLES,  BOOK CHAPTERS AND INVITED REVIEWS 
 

2011 -

http://www.israelagri.com/?CategoryID=484&ArticleID=1146

Hariton-Shalev, A. and Altstein, M. (2015)
Pheromonotropic and melanotropic PK/PBAN receptor: Differential ligand receptor interactions.
Peptides, 63, 81-89. 

Altstein, M., Hariton, A. and R.J. Nachman (2013)
Invited review: FXPRLamide (pyrokinin/PBAN) family.
In: Handbook of Biologically Active Peptides (Kastin, A. Ed.), Chapter 37, 255-266.

Altstein, M. (2013)
Invited review: Pheromones peptides.
In: Handbook of Biologically Active Peptides (Kastin, A. Ed.), Chapter 258, 1889-1898.

Hariton-Shalev, A., Shalev, M., Adir, N., Belausov, E. and Altstein, M. (2013)
Structural and functional differences between pheromonotropic and melanotropic PK/PBAN receptors
Biochimica et Biophysica Acat-General Subjects, 1830, 5036-5048.

Sapir, A., Hariton-Shalev, A., Skalka, N., Bronshtein, A. and Altstein, M. (2013)
Development of an enzyme-linked immunosorbent assay and a beta-1 adrenergic receptor-based assay for monitoring the drug atenolol
Environmental Toxicology and Chemistry, 32 ( 3), 585-593.

Van Emon, J.M., Chuang, J.C., Bronshtein, A and Altstein, M. (2013)
Determination of polychlorinated biphenyls in soil and sediment by selective pressurized liquid extraction with immunochemical detection.
Science of the Total Environment, 463-464, 326-333.

Bronshtein, A., Krol, A., Schlesinger, H. and Altstein,M. (2012)
Development of immunochemical methods for purification and detection of the steroid drug medroxyprogesterone acetate.
J. Environ. Protection, 3, 624-639.

Bronshtein, A., Chuang, J.C., Van Emon, J.M. and Altstein, M. (2012)
Development of a multi-analyte enzyme linked immunosorbent assay for permethrin and aroclors and its implementation for analysis of soil/sediments and house dust extracts
J. Agri. Food Chem. 60, 4235-4242.

Skalka, N.**, Krol, A., Schlesinger, H. and Altstein, M. (2011)
Monitoring of non-steroid anti-inflammatory drugs: development of immunochemical methods for purification and detection of indomethacin.
Anal. Bioanal. Chem, 400, 3491-3504

\\\\\\\\\Salev, M. and Altstein, M. (2011).
SololSol gel entrapped levonorgestrel antibodies: Activity and structural changesas a functias a function of different polymer formats.
Mate Materials, 4, 469-486. 

2005 - 2010,
Altstein, M., Ben Aziz, O., Skalka, N., Bronshtein, A., Chuang, J.C. and Van Emon, J.M. (2010)
Development of an immunoassay and a sol gel based immunoaffinity purification method for coplanar PCBs
Analytica Chimica Acta,.675, 138-147.

Shalev, M., Bardugo, M., Nudelman, A., Krol, A., Schlesinger, H., Bronshtein, A. and Altstein,M. (2010)
Monitoring of progestins: development of immunochemical methods for purification and detection of levonorgestrel.
Analytica Chimica Acta,. 665, 176-184.

Hariton, A., Ben Aziz, O., Davidovitch, M. and Altstein, M. (2010)
Bioavailability of backbone cyclic PK/PBAN antagonists: inhibition of sex pheromone biosynthesis elicited by the natural mechanism in Heliothis peltigera females.
FEBS Journal, 277, 1035-1044.

Nachman, R.J., Ben Aziz, O., Davidovitch, M., Kaczmarek, K., Zabrock, J., Williams, H.W., Strey, A., and Altstein, M. (2010)
A novel dihydroimidazoline, trans-Pro mimics PK/PBAN analog is a selective PK/PBAN agonist.
Frontiers in Bioscience, 2, 195-203.

Altstein, M. and Nässel, R. (2010).
Invited review: Neuropeptide signaling in insects
In: Neuropeptide Systems as Targets for Parasite and Pest Control. (Geary T.G and Maule, A.G. Eds).
Landes Biosciences, In press.

Ben Yosef T, Bronshtein, A., Ben Aziz, O., Davidovitch, M., Tirosh, I., and Altstein, M. (2009).
PBAN receptor: employment of anti-receptor antibodies for its characterization and for development of a microplate binding assay
J. of Insect Physiol., 55, 825-833.

Hariton, A., Ben-Aziz, O., Davidovitch,M., Nachman, R.J. and Altstein, M. (2009)
Bioavailability of β-amino acid and C-terminally derived PK/PBAN analogs
Peptides, 30, 2174-2181 

Nachman, R.J., Wang, X. J., Etzkorn, F., Ben Aziz, O., Davidovitch, M. Kaczmarek, K., Zabrocki, J.and Altstein, M.(2009). 
Evaluation of a pyrokinin/PBAN analog containing an (E)-alkene, trans-Pro isostere identifies the Pro orientation for activity in four diverse pyrokinin bioassays in four pyrokinin bioassays.
Peptides, 30, 1254-1259..

Hariton, A., Ben-Aziz, O., Davidovitch,M., Nachman, R.J. and Altstein, M. (2009)
Bioavailability of insect neuropeptides: The PK/PBAN family as a case study.
Peptides, 30, 1034-1041.

Nachman, R.J., Ben Aziz, O., Davidovitch, M., Zubrzak, P., Isaac, R.E., Strey, A., Reyes-Rangel, G., Juaristi, E., Williams, H.W. and Altstein, M. (2009)
Biostable β-amino acid pyrokinin/PBAN analogs: Agonist and antagonist properties.
Peptides, 30, 608-615.

Nachman, R.J., Teal, P.E.A.., Ben Aziz, O., Davidovitch, M., Zubrzak, P. and Altstein, M. (2009)
An amphiphilic, PK/PBAN analog is a selective pheromonotropic antagonist that penetrates the cuticle of a heliothine insect.
Peptides, 30, 616-621.

Piersma, A.H., Luijten, M., Popov, V., Tomenk, V., Altstein, M., Kagampang, F. and Schlesinger H. (2009).
Invited chapter: Pharmaceuticals.
In: Endocrine-disrupting chemicals in food
(Shaw, I. Ed.), University of Canterbury, New Zealand, Chapter 18, pp. 459-518.

Altstein, M. and Hariton, A. (2009) 
Invited review: Rational design of insect control agents: The PK/PBAN family as a study case.
In: Biorational Control of Arthropod Pests: Application and Resistance management.
(Ishaaya,I. and Horowitz,R, Eds), Springer.Chapter 3, pp. 49-81.

Altstein, M. (2009)
Invited chapter: Neuropeptides
In: Encyclopedia of Insects (Resh, V. and Carde, R. Eds.) Academic Press, 691-695.

Zheng, L, Njauw, C.H. Lytle, C., Altstein, M. and Green, M.M. (2007)
Cloning and Characterization of the Pheromone Biosynthesis Activating Neuropeptide Receptor Gene in Spodoptera littoralis.
Gene., 15, 20-30.

Altstein, M., Ben-Aziz, O., Zeltser, I. , Bhargava, K, Davidovitch, M., Strey, A., Pryor, N. and Nachman, R.J. (2007).
Inhibition of PK/PBAN-mediated functions in insects: Discovery of selective and non-selective inhibitors
Peptides, 28, 574-584.

Altstein, M and Bronshtein, A. (2007)
Invited review: Sol gel immunoassays and immunoaffinity chromatography 
In: Immunoassay and Other Bioanalytical Techniques, (Van Emon, J. Ed.) CRC Press, Chapter 15, pp.357- 384.

Kaware, M., Bronshtein, A., Safi, J., Van Emon, J.M., Chuang, J.C., Hock, B., Kramer, K. and Altstein, M. (2006).
Enzyme-linked immunosorbent assay (ELISA) and sol-gel-based immunoaffinity purification (IAP) of the pyrethroid bioallethrin in food and environmental samples
J Agric Food Chem. 54, 6482-6492.

Ben-Aziz, O., Zeltser, I. , Bhargava, K, Davidovitch, M. and Altstein, M. (2006).
Backbone cyclic pheromone biosynthesis activating neuropeptide (PBAN) antagonists: Inhibition of melanization in the moth Spodoptera littoralis (Insecta: Lepidoptera).
Peptides. 27, 2147-2156.

Butovsky, E., Juknat, A., Elbaz, J., Shabat-Simon, M., Eilam, R., Zangen, A., Altstein, M. and Vogel, Z. (2006)
Chronic exposure to ?9-tetrahydrocannabinol down regulates oxytocin and oxytocin-associated neurophysin in specific brain areas.
Molecular and Cellular Neuroscience. 31, 795-804.

Altstein, M. (2006)
Invited chapter: Peptide pheromones.
In: Handbook of Biologically Active Peptides (Kastin, A. Ed.), Elsevier, San Diego,.Chapter 210, p1505-1513.

Ben-Aziz, O., Zeltser, I. and Altstein, M. (2005).
PBAN selective antagonists: Inhibition of PBAN induced cuticular melanization and sex pheromone biosynthesis in moths.
J. Insect Physiol. 51, 305-314.

2004 - 2000
Altstein, M, (2004)
Role of neuropeptides in sex pheromone production in moths
Peptides, 25, 1491-1501.

Altstein, M. (2004) 
Peptide pheromones: an overview.
Peptides, 25, 1373-1376.

Altstein, M (2003)
Novel insect control agents based on neuropeptide antagonists: The PK/PBAN family as a case study
Journal of Molecular Neuroscience, 22, 147-158.

Altstein, M., Ben-Aziz, O., Bhargava, K., Li, Q., and Martins-Green, M. (2003)
Histochemical localization of the PBAN receptor in the pheromone gland of Heliothis peltigera 
Peptides, 24, 1335-1347.

Altstein, M. (2003)
Invited chapter: Neuropeptides.
In: Encyclopedia of Insects (Resh, V. and Carde, R. Eds.) Academic Press, 782-785.

Altstein, M. (2002)
Insect neuropeptide antagonists.
Biopolymers (Peptide Science), 60, 460-473.

Zeltser, I., Ben-Aziz, O., Schefler, I., Bhargava, K., Altstein, M. and Gilon, C. (2001)
Insect neuropeptide antagonist Part II: Synthesis and biological activity of backbone cyclic and precyclic PBAN antagonists.
J. Peptide Res., 58, 1-13.

Altstein, M., Ben-Aziz, O., Daniel, S., Zeltser, I., and Gilon, C. (2001)
Pyrokinin/PBAN radio-receptor assay: development and application for the characterization of a putative receptor from the pheromone gland of Heliothis peltigera
Peptides, 22, 1379-1389.

Altstein M., Bronshtein A., Glattstein, B., Zeichner, A., Tamiri, T. and Almog, J.(2001).
Immunochemical approaches for purification and detection of TNT traces by antibodies entrapped in a sol-gel matrix.
Anal. Chem.73, 2461-2467.

Altstein, M. and Gilon, C. (2001)
Invited review: Insect neuropeptide agonists and antagonists: rational approaches for insect control.
In: Biochemical Sites of Insecticide Action and Resistance (Ishaaya, I. Ed.), Springer- Verlag Berlin  Heidelberg, 151-166.

Zeltser I., Gilon, G., Ben-Aziz, O.,Schefler, I. and Altstein, M. (2000)
Discovery of a linear lead antagonist to the insect pheromone biosynthesis activating neuropeptide (PBAN).
Peptides. 21, 1457-1467.

Bronshtein, A., Aharonson, N., Turniansky, A. and Altstein, M. (2000).
Sol-gel based immunoaffinity chromatography: application to nirtroaromatic compounds
Chem. Mater. 12, 2050-2058

Altstein, M., Aharonson, N., Segev, G.,  Ben-Aziz, O., Avnir, D., Turniansky, A. and Bronshtein, A. (2000).
Sol-gel based enzymatic assays and immunoassays for residue analysis        Italian Journal of Food Science, 12, 191-206.  

Altstein, M., Ben-Aziz, O., Schefler, I., Zeltser, I. and Gilon, C. (2000)
Advances in the application of neuropeptides in insect control
Crop Protection, 19, 547-555.


1999 - 1989
Altstein, M., Gabay, T., Ben Aziz, O., Daniel, S., Zeltser, I. and Gilon, C. (1999).
Characterization of a putative pheromone biosynthesis activation neuropeptide (PBAN) receptor from the pheromone gland of Heliothis peltigera.
Invertebrate Neurosci.4, 33-40.

Altstein, M., Ben-Aziz, O., Daniel, S., Schefler, I. Zeltser, I. and Gilon, C. (1999).
Backbone cyclic peptide antagonists, derived from the insect pheromone biosynthesis activating neuropeptide (PBAN), inhibit sex pheromone biosynthesis in moths.
J.Biol. Chem . 274, 17573-17579.

Altstein, M., Segev, G., Aharonson, N., Ben Aziz, O., Turniansky, A. and Avnir,  D. (1998).
Sol-gel entrapped cholinesterases: A microtiter plate method for monitoring anti-cholinesterase compounds.
J. Agric. Food Chem. 46, 3318-3324.

Gilon, C., Zeltser, I, Daniel, S., Ben-Aziz, O. Schefler, I. and Altstein, M. (1997). 
Rationally designed neuropeptide antagonists: A novel approach for generation of  environmentally friendly insecticides. 
Inverebrate Neurosci. 3, 245-250.

Bronshtein, A., Aharonson, N., Avnir, D., Turniansky, A. and Altstein, M. (1997).
Sol-gel matrices doped with atrazine antibodies: Atrazine binding properties.
Chem. Mater. 9, 2632-2639.

Pintov, S., Lahat, E., Altstein, M., Vogel, Z. and Barg, Y. (1997).    
Acupuncture and the opioidergic system: Implications in the management of migraine headaches in children.
Pediatric Neurology, 17, 129-133.

Altstein, M. and Parnas, I. (1997)
Trends in Invertebrate neurosciences.
 Invertebrate Neurosci. 79-80.

Davis, N.T., Homberg, U., Teal, P.E.A., Altstein. M. and Hildebrand, J.G. (1996).
Neuroanatomy and immunocytochemistry of the neurosecretory system of the subesophageal ganglion of the tobacco hawkmoth, Manduca sexta: Immunoreactivity to PBAN and other neuropeptides. 
Microscopy Res. Tech., 35, 201-229.

Turniansky, A., Avnir, D., Bronshtein, A., Aharonson, N. and Altstein. M. (1996). 
Sol-gel entrapment of monoclonal anti-atrazine antibodies.
 J. Sol-Gel Sci. Tech. 7, 135-143.

Altstein, M., Gazit, Y., Ben Aziz, O., Gabay, T., Marcus, R., Vogel, Z. and Barg, J. (1996).
Induction of cuticular melanization in Spodoptera littoralis larvae by PBAN/MRCH: Development of a quantitative bioassay and structure function analysis.
Arch. Insect Biochem. Physiol. 31, 355-370.

Altstein, M., Dunkelblum, E., Gazit, Y., Ben Aziz, O., Gabay, T.,Vogel, Z. and Barg, J. (1996).
Structure-function analysis of PBAN/MRCH: A basis for antagonist design.
In: Modern Agriculture and the Environment (Rosen, D. et al., Eds). Kluwer Academic Publishers, 109-116.

 Altstein, M., Ben-Aziz, O., Gabay, T., Gazit, Y. and Dunkelblum, E. (1996).   
Structure-function relationship of PBAN/MRCH.         
In: Insect Pheromone Research: New Directions (R.T., Carde and A.K., Minks, Eds.) Chapman and Hall, 56-63.

Altstein. M., Dunkelblum, E., Gabay, T., Ben Aziz, O., Schafler, I. and Gazit, Y. (1995).    
PBAN-induced sex pheromone biosynthesis in Heliothis peltigera: Structure, dose and  time-dependent analysis.
 Arch. Insect Biochem. Physiol. 30, 309-317.

Aharonson, N., Altstein, M., Avidan, G.,  Avnir, D., Bronshtein, A., Lewis, A., Lieberman, K., Ottolenghi, M., Polevaya, Y., Rottman, C., Samuel, J., Shalom, S., Strinkovski, A. and Turiansky, A. (1994).
Recent Developments in Organically Doped Sol-Gel Sensors: A Microns-Scale Probe; Successful Trapping of Purified Polyclonal Antibodies; Solutions to the Dopant-Leaching Problem. 
In: Better Ceramics Through Chemistry, VI (C. Sanchez, M.L. Mecartney, C.J. Brinker  and A. Cheetham, Eds),  Materials Research Society Symposium Proceedings Vol. 346, pp. 519-530.


Altstein, M., Dunkelblum, E., Ben-Aziz, O., Meisner, J., and Gazit, Y.  (1994).
PBAN/MRCH content variations in color polymorphic Spodoptera littoralis moths.
In: Insect Neurochemistry and Neuropharmacology 1993 (A.B. Borkovek and M.J. Loeb, Eds.) CRC Press, Cleveland, Ohio. 219-222.

Altstein, M., Ben-Aziz, O. and Gazit, Y. (1993).
Pheromone biosynthesis activating neuropeptide (PBAN) and color polymorphism: An immunochemical study in Spodoptera littoralis.
J. Insect Physiol. 40, 303-309.

Altstein, M., Aharonson, N. and Menn, J.J. (1993).
New targets for insect management in crop protection.
Arch. Insect Biochem. Physiol. 22, 5-12.

Altstein, M., Gazit, Y. and Dunkelblum, E. (1993).
Neuroendocrine control of sex pheromone biosynthesis in Heliothis peltigera.
Arch. Insect Biochem. Physiol. 22, 153-168.

Gazit Y. Dunkelblum, E. Ben-Aziz, O. and Altstein, M. (1992).
Immunochemical and biological analysis of pheromone biosynthesis activating  neuropeptide (PBAN) In Heliothis peltigera.
Arch. Insect Biochem. Physiol. 19, 247-260

Meidan, R., Altstein, M., Girsh, E. (1991).
Biosynthesis and release of oxytocin by granulosa cells derived from preovulatory bovine follicles: Effect of forskolin and IGF-I.
Biol. Reprod. 46., 715-720.

Gazit, Y., Dunkelblum, E., M. Benichis and Altstein, M. (1990).
Effect of synthetic PBAN and derived peptides on sex pheromone biosynthesis in Heliothis peltigera (Lepidoptera: Noctuidae).
Insect Biochem. 20, 853-858.

Altstein, M., Gazit, Y. and Dunkelblum, E. (1990).
Regulation of sex pheromone biosynthesis in Chrysodeixis chalcites and Heliothis peltigera by PBAN.
In: Insect Neurochemistry and Neurophysiology 1989 (A.B. Borkovec and E.P. Masler Eds.), Humana Press, Clifton, NJ. 303-307.

Altstein, M. (1989).
Insect Neuropeptides.
Phytoparasitica, 17, 163-166.

Dunkelblum, E., Maman, H., Altstein, M. and Goldschmidt, Z. (1989).
Acetylation of alcohols in the pheromone biosynthesis of the tomato looper Chrysodeixis chalcites (Lepidoptera: Noctuidae).
Insect Biochem. 19, 523-526.

Altstein, M., Harel, M., and Dunkelblum, E. (1989).
Effect of a brain factor on sex pheromone biosynthesis in the tomato looper Chrysodeixis chalcites (Lepidoptera: Noctuidae).
Insect Biochem. 19, 645-649.

1988 - 1977
Altstein, M
. and Gainer, H. (1988).
Differential biosynthesis and post-translational processing of vasopressin and oxytocin in rat brain during embryonic and postnatal development.
J. of Neurosci. 8, 3967-3977.

Altstein, M., Whitnall, M., House, S., Key, S. and Gainer, H. (1988).
An immunochemical analysis of oxytocin and vasopressin prohormone processing in vivo.
Peptides, 9, 87-107.

Gainer, H., Altstein, M. and Hara, Y. (1988).
Oxytocin and Vasopressin: After the genes, what next?
In: Neurosecretion (B.T. Pickering, J.B. Wakerley and A.J.S. Summerlee Eds.), Plenum Press. pp. 1-10.

Gainer, H., Altstein, M., Whitnall, M. and Wray, S. (1988).
The biosynthesis and secretion of oxytocin and vasopressin.
In: Physiology of Reproduction. (Knobil, E., Neil, J.D., Ewing, L.L.,Markert, C.L., Greenwald, G.S. and  Pfaff, D.W. Eds.). Raven Press, Vol: 2, pp. 2265-2289.

Altstein, M., Dudai, Y. and Vogel, Z. (1987).
Angiotensin-converting enzyme is associated with Torpedo californica electric organ membranes.
J. of Neurosci. Res. 18, 333-340

Gainer, H., Altstein, M. and Whitnall, M.H. (1987).
The cell biology and development of vasopressinergic and oxytocinergic neurons.
Progress in Brain Research. 72, 153-161.

Parish, D.C., Tuteja, R., Altstein, M., Gainer, H. and Loh, Y.P. (1986).
Purification and characterization of a paired basic residue specific prohormone converting enzyme from bovine pituitary neural lobe secretory vesicles.
J. of Biological Chemistry. 261, 14392-14397.

Altstein, M., Dudai, Y. and Vogel, Z. (1984).
Enkephalin degrading enzymes are present in the electric organ of  Torpedo californica.
FEBS Letts. 166, 183-188.

De Simoni, M.G., Guardabasso, V., Algeri, S., Blumberg, S., Vogel, Z.and Altstein, M. (1984).
Enkephalinase inhibitors potentiate enkephalin central effects.
In: Analgesia and Enkephalinases: Quo Vadis? (Biogegrain, R., C J., Moree, M.,  Muyard, J.P., Roncucci, R., Eds.) pp. 243-250.

Vogel, Z. and  Altstein, M. (1984).
Inhibition of enkephalinase and of aminopeptidase.
In: Analgesia and enkephalinases: Quo Vadis? Biogegrain, R., Cros, J., Moore, M., Muyard, J.P., Roncucci, R., Eds.) pp. 213-221.

Altstein, M., Bachar, E., Vogel, Z. and Blumberg, S. (1983).
Protection of enkephalins from enzymatic degradation utilizing selective metal chelating inhibitors.
Eur. J. Pharmacol. 91, 353-361.

De Simoni, M.G., Altstein, M. Blumberg, S., Fidecka, S., Vogel, Z. and Algeri, S. (1983).
Potentiation of enkephalin central effects after administration of peptidase inhibitors.
In: Degradation of Endogenous Opioids: Its Relevance to Human Pathology and Therapy (Ehrenpreis, S. and Sicuteri, F., Eds.) Raven Press, pp. 121-127.

Altstein, M. Blumberg, S. and Vogel, Z. (1982).
Phosphoryl-Leu-Phe: A highly potent inhibitor of the degradation of enkephalin by enkephalinase.
Eur. J. Pharmacol. 76, 299-300.

Altstein, M. Blumberg, S. and Vogel, Z. (1982).
Inhibition of enkephalin degrading enzymes by metal chelating reagents.
Adv. in Biochem. Psychopharmacol. 33, 261-270.

Algeri, S., Altstein, M., De Simone, G.M. and Guardabasso, V. (1981).
In vivo potentiation of [D-Ala2]Met-enkephalin amide. Central effects after administration of an enkephalinase inhibitor.
Eur. J. Pharmacol. 74, 261-262.

Blumberg, S., Vogel, Z. and Altstein, M. (1981).
Inhibition of enkephalin-degrading enzymes from rat brain and of thermolysin by amino acid hydroxamates.
Life Sci. 28, 301-306.

Altstein, M., Dudai, Y. and Vogel, Z. (1981).
Benzodiazepine receptors in chick retina: development and cellular localization.
Brain Res. 206, 198-202.

Altstein, M., Mittman, S. and Vogel, Z. (1981).
The effect of barbiturates on the degradation of enkephalin by brain enzymes.
Life Sci. 28, 185-191.

Vogel, Z. and Altstein, M. (1980).
Inactivation of enkephalin by brain enzyme.
Prog. Biochem. Pharm. 16, 49-59.

Altstein, M. and Vogel, Z. (1980).
On the inactivation of enkephalin by enkephalinase.
In: Neurotransmitters and their Receptors (Littauer, U.Z., Dudai, Y., Silman, I., Teichberg, V.I. and  Vogel, Z., Eds.) Wiley & Sons, pp. 497-507.

Vogel, Z. and Altstein, M. (1980).
Degradation of enkephalin by two brain enzymatic activities.
In: Endogenous and Exogenous Opiate Agonists and Antagonists (Way, E.L., Ed.), Pergamon Press, New York, pp. 353-356.

Vogel, Z. and Altstein, M. (1979).
The effect of puromycin on the biological activity of Leu-enkephalin.
FEBS Lett. 98, 44-48.

Vogel, Z., Miron, T., Altstein, M. and Wilchek, M. (1978).
Spontaneous inactivation of enkephalin.
Biochem. Biophys. Res. Commun. 85, 226-233.

Vogel, Z. and Altstein, M. (1977).
The absorption of enkephalin to porous polystyrene beads. A simple assay for enkephalin hydrolysis.
FEBS Letts. 80, 332-336.


 

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