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Institute of Agricultural Engineering
*Institute of Animal Scienc
Gilat Research Center
Newe Ya'ar Research Center
Institute of Plant Protection
Institute of Plant Science
Postharvest and Food Sciences
Institute of Soil, Water & Environmental Sciences
Institute of Animal Scienc

Institute of Animal Science - Central ARO Campus, Rishon Leziyon & Rehovot

Department of Ruminant Science

  1. Dvir Hay e-mail Team: Hay Dvir, Mugagga Kalyesubula, Alex Rosov, Tamir Alon
    Metabolic efficiency as a measure of pregnancy performance in highly prolific sheep
    Ruminants breeding for intensive farming resulted in highly productive animals either in the number of fetuses per pregnancy and/or in their milk yield. However, as energy demands dramatically increase during late gestation and early lactation, the metabolic load on liver gluconeogenesis often becomes too high and may involve metabolic pathologies collectively referred to as pregnancy toxemia. The research aims at developing an exciting novel approach to characterize and quantitate metabolic efficiency, with the ultimate goal of identifying individuals with potential for improved pregancy performance.
  2. Dvir Hay e-mail Team: Hay Dvir, Mugagga Kalyesubula, Alex Rosov
    Fatty liver in sheep as a model system for liver disease in human
    Fatty Liver (FL) develops when the hepatic synthesis and uptake of lipids exceed their rate of breakdown and export out of the liver. Investigation of physiological and pathophysiological processes modulating the liver fat content are of significance to a wide range of metabolic derangements common to diseases of our modern era, in particular non-alcoholic fatty liver disease, but also to obesity T2D and metabolic syndrome. We thus aim to establish a new large mammal model system for consistent studies of FL, based on sheep, using over nutrition as a means to induce hepatic fat accumulation.
  3. Dvir Hay e-mail Team:Hay Dvir, Elisha Gootwine, Ron Ofri, Eyal Banin, Hen Honig
    Gene therapy of day blindness in sheep
    This is an ongoing project started with the discovery impaired day vision in newborn lambs over 10 years ago. Since then, gene therapy has been successfully utilized to restore their vision. Currently, we are still breeding these blind sheep for research purposes in order to develop improved methods for virus-mediated gene delivery, which are of significance for similar clinical gene therapy attempts to cure day blindness in human.
  4. Gershon Eran e-mail Team:'Dr. Hen Honig
    Establishment of an in vivo model for embryo implantation in ruminants using trophoblast-specific gene manipulation system
    In the last few years, viral transgenesis has become a popular approach to deliver genes in different cell types. In order to address the urgent need for molecular in vivo models for the embryo implantation in ruminants, we purpose herein to establish a trophoblast-specific lentiviral gene transfer system in sheep. Developing such a model will provide a tool to explore in vivo molecular mechanisms that might be significant for embryo implantation in ruminants. The knowledge accumulate using this model might might better our understanding of pathological conditions and could potentially lead to the development of novel strategies for treating, improving or handling and curing poor fertility.
  5. Jami Elie e-mail Team: Dr. Elie Jami,Msc student - Bar Levy
    Characterization of the cow rumen microbiome and its effect on the host
    Ruminant animals have significantly impacted human society by providing animal work, wool, and most importantly, meat and dairy products. Ruminants are unique because they can convert indigestible plant biomass into nutritionally-rich human foods, serving as intermediaries between light energy harvested via photosynthetic plants to consumable products for humans. This feat is possible through the large microbial population residing within its digestive tract, fermenting the food, giving access to energy for the animal. Recently, and in many fields of studies, the microbiome - the total microbial community within a given environment - was shown to exert a tremendous impact on its host animal such as the microbiome inside the digestive system of the cow. In our lab, we aim to characterize this remarkable microbial population and study its effect on the cow and the environment.
  6. Zachut Maya e-mail Team:Dr. Uzi Moallem
    Affecting immuno-metabolism to improve stress response in dairy cows
    Characterizing immuno-metabolic profile of late pregnant and early postpartum dairy cows, examining dietary supplements that can improve immun-metabolic state and mitigate stress, effects on stress biomarkers in blood and tissues, the combined effects of metabloic stress and environmental heat stress on dairy cows. Work involves experiments with cows and molecular biology. Seeking for highly motivated students.
  7. Zachut Maya e-mail Team:Dr. Uzi Moallem
    Effects of omega-3 on immune response of transition dairy cows
    The research will examine the effects of dietary omega-3 on immune response of high yielding dairy cows during the transition period, and the effects on the newborn calves. The work will include experiments with cows and lab work involving ELISA, flow cytometry, and molecular biology.

Poultry and Aquaculture

  1. Biran Yakob e-mail Team:Dr. Avner Cnaani
    Genome editing in tilapia to improve productivity
    New methods for genome editing were recently developed, now allowing the induction of gene knockout in fish. Tilapia is the leading fish in Israeli as well as in global aquaculture. We are currently establishing these methods to employ them in tilapia. The project combines cutting-edge tools with classical endocrine research. We are looking for highly motivated and ambitious students who wish to make impact on aquaculture research and industry.
  2. Einat Miriam e-mail Team: A tight collaboration with Dr. Eyal Seroussi in all bioinformatics aspects of the project and with Yuval Cinnamon in production of transgenic chickens
    The role of the adipose tissue in the control of appetite and reproduction: Functional and evolutional perspectives
    The lab is leading a breakthrough study for understanding the role of adipose tissue in chickens and the evolutionary differences in this role between birds and mammals. New genes and gene functions are being explored using top of the art techniques The work combines diverse research methods in the fields of molecular biology, genomics, bioinformatics, and physiology, linking physiological characteristics to gene function. The emphasis in this work will be on understanding the existing dialogue between adipose tissue and the control centers in the brain responsible for hunger/satiety and reproduction. A highly motivated student with experience in molecular biology methodologies, will be highly apreciated.
  3. Noam Meiri e-mail Team:Prof. Aron Weller Bar Ilan
    Maternal high fat diet and its consequences on epigenetic regulation of metabolic and physiological phenotypes of its offspring and next generation's inheritance.
    Obesity and metabolic disorders are an ever growing epidemic in the modern world where the access to high fat, energy-dense foods is much easier than before. Maternal high fat diet during gestation and lactation and even during childhood has long-term consequences on the offspring’s metabolic phenotype which affect the offspring's life and can even be inherited to next generations. We study the epigenetic regulation of these phenomena.
  4. Noam Meiri e-mail Team: Not Applicable
    Epigenetic regulation of thermotolerance acquisition and memory
    Thermal stress during the critical postnatal sensory developmental period determines a delicate balance of a probably adjustable stress response set-point. The adjustment of the thermal-response is determined by hypothalamic neuronal network remodeling which might be accompanied by alteration in the repertoire of expressed proteins and in variation in neuronal hypothalamic cell populations. We are identifying epigenetic changes associated with heat stress response in chicks during thermal control establishment and as a consequence during heat challenge later in life.
Updated on: 08/03/18 10:16
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